Aras Cengiz, Ocakoglu Ozcan, Akova Nilufer
Department of Ophthalmology, Medical School of Cerrahpasa, Istanbul University, Ataköy-Istanbu, Turkey.
Int Ophthalmol. 2004 Jul;25(4):225-31. doi: 10.1007/s10792-005-5014-4. Epub 2005 Sep 29.
To measure choroidal blood flow from foveal region in the eyes with idiopathic macular hole.
Thirteen patients with macular hole and 20 age-matched healthy subjects were included into the study. While group 1 consisted of 13 eyes of idiopathic stage 4 macular hole, seven fellow eyes of the same patients with stage 1a macular hole formed the group 2. The control group (group 3) comprised the randomly selected eye of 20 age-matched healthy subjects. Mean values of blood perfusion parameters that were composed of volume, flow and velocity, were recorded from foveal region of fundus using Heidelberg Retinal Flowmeter (HRF). The differences between the three groups were compared with unpaired t-test, Wilcoxon Signed Rank and Fisher's Exact test using statistical package program.
The mean blood volume and velocity in the eyes with stage 4 macular hole (group 1) and in the eyes with stage 1a macular hole (group 2) were both significantly lower than the eyes in control eyes (group 3) (p < 0.05, unpaired t-test). Although, the mean blood "flow" parameter of group 2 was significantly lower than group 3 ( p < 0.05, unpaired t-test), there was no statistical difference in the "flow" parameter between group 1 and group 3 (p > 0.05, unpaired t-test). The comparison between group 1 and group 2 revealed no significant difference in any perfusion parameter (p > 0.05, Wilcoxon Signed Rank Test).
Although, it may be result of macular hole, not necessarily the cause of it, these findings suggest that the eyes with idiopathic macular hole are associated with reduced foveolar blood flow. The measurement of the foveolar blood flow from choriocapillaris may be useful for identifying the subjects who have increased risk of development of macular hole in future. The study showed the association of a decrease in foveolar choroidal blood flow in eyes with idiopathic macular hole using HRF. Authors suggested that quantitative measurement of foveolar choroidal blood flow may be helpful for identifying the subjects who have increased risk of development of idiopathic macular hole.
测量特发性黄斑裂孔患者眼内黄斑中心凹区域的脉络膜血流。
本研究纳入了13例黄斑裂孔患者和20名年龄匹配的健康受试者。第1组由13只特发性4期黄斑裂孔眼组成，同一患者的7只1a期黄斑裂孔对侧眼组成第2组。对照组（第3组）包括随机选取的20名年龄匹配健康受试者的眼睛。使用海德堡视网膜血流仪（HRF）从眼底黄斑中心凹区域记录由体积、流量和速度组成的血液灌注参数的平均值。使用统计软件包程序，通过不成对t检验、Wilcoxon符号秩检验和Fisher精确检验比较三组之间的差异。
4期黄斑裂孔眼（第1组）和1a期黄斑裂孔眼（第2组）的平均血容量和血流速度均显著低于对照眼（第3组）（p<0.05，不成对t检验）。虽然第2组的平均血流参数显著低于第3组（p<0.05，不成对t检验），但第1组和第3组之间的血流参数无统计学差异（p>0.05，不成对t检验）。第1组和第2组之间的比较显示，任何灌注参数均无显著差异（p>0.05，Wilcoxon符号秩检验）。
虽然这可能是黄斑裂孔的结果，而不一定是其原因，但这些发现表明，特发性黄斑裂孔患者的黄斑中心凹血流减少。测量脉络膜毛细血管的黄斑中心凹血流可能有助于识别未来发生黄斑裂孔风险增加的受试者。本研究使用HRF显示了特发性黄斑裂孔患者眼内黄斑中心凹脉络膜血流减少的相关性。作者认为，定量测量黄斑中心凹脉络膜血流可能有助于识别特发性黄斑裂孔发生风险增加的受试者。
