Doi Y, Shibutani T, Moriwaki Y, Kajimoto T, Iwayama Y
Department of Dental Materials and Technology, School of Dentistry, Asahi University, Hozumi, Gifu, Japan.
J Biomed Mater Res. 1998 Mar 15;39(4):603-10. doi: 10.1002/(sici)1097-4636(19980315)39:4<603::aid-jbm15>3.0.co;2-7.
The dissolution behavior of sintered carbonate apatite was investigated in a 10 mM/L acetic acid solution adjusted to pH 5.0 at 37 degrees C, and compared to that of sintered hydroxyapatite and bone apatite for the purpose of establishing some similarities between the physicochemical dissolution of apatite biomaterials in vitro and their ability to be resorbed by osteoclasts in vivo. Both the sintered carbonate apatite and the bone apatite dissolved to an appreciable extent. Their solution compositions changed in an almost identical manner until toward the end of the reaction. The solution compositions for sintered carbonate apatite at 30 s was comparable with that for sintered hydroxyapatite at 3.8 days with respect to the degree of supersaturation, indicating that the former specimen is much more soluble than the latter specimen. Osteoclasts which were obtained from the long bones of 1-day-old neonatal rabbits resorbed bone and sintered carbonate apatite, but not sintered hydroxyapatite. These findings suggest that sintered carbonate apatites, which have characteristics that can be favorably compared with those of bone, especially with respect to its reactivity to acid media, would be useful as bioresorbable bone substitutes.
在37℃下将10 mM/L乙酸溶液调节至pH 5.0，研究烧结碳酸磷灰石的溶解行为，并将其与烧结羟基磷灰石和骨磷灰石的溶解行为进行比较，目的是确定磷灰石生物材料在体外的物理化学溶解与其在体内被破骨细胞吸收的能力之间的一些相似性。烧结碳酸磷灰石和骨磷灰石都有相当程度的溶解。直到反应接近尾声，它们的溶液成分变化方式几乎相同。就过饱和度而言，烧结碳酸磷灰石在30 s时的溶液成分与烧结羟基磷灰石在3.8天时的溶液成分相当，这表明前者比后者的溶解性大得多。从1日龄新生兔的长骨中获取的破骨细胞能够吸收骨和烧结碳酸磷灰石，但不能吸收烧结羟基磷灰石。这些发现表明，烧结碳酸磷灰石具有与骨相似的特性，特别是在对酸性介质的反应性方面，有望作为可生物吸收的骨替代物。
