人类病原体来源的肽激活自身反应性T细胞。
Activation of autoreactive T cells by peptides from human pathogens.
作者信息
Hausmann S, Wucherpfennig K W
机构信息
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
Curr Opin Immunol. 1997 Dec;9(6):831-8. doi: 10.1016/s0952-7915(97)80186-0.
Abstract
Activation of autoreactive T cells is a necessary-but not sufficient-step in the development of T cell mediated autoimmunity. Autoreactive T cells can be activated by viral and bacterial peptides that meet the structural requirements for MHC molecule binding and T cell receptor recognition. Due to the degenerate nature of MHC class II molecule binding motifs and a certain degree of flexibility in T cell receptor recognition, such microbial peptides have been found to be quite distinct in their primary sequence from the self-peptide they mimic.
摘要
自身反应性T细胞的激活是T细胞介导的自身免疫发展过程中的一个必要但非充分步骤。自身反应性T细胞可被符合MHC分子结合和T细胞受体识别结构要求的病毒和细菌肽激活。由于MHC II类分子结合基序的简并性以及T细胞受体识别的一定程度的灵活性，已发现此类微生物肽在其一级序列上与它们所模拟的自身肽有很大不同。
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本文引用的文献
1
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J Clin Invest. 1997 Sep 1;100(5):1114-22. doi: 10.1172/JCI119622.
2
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3
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