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席夫碱是否参与哺乳动物肝脏中δ4-3-氧代甾体5α-或5β-还原酶的作用机制？

Is a Schiff base involved in the mechanism of the delta4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver?

作者信息

Wilton D C

出版信息

Biochem J. 1976 Jun 1;155(3):487-91. doi: 10.1042/bj1550487.

DOI:10.1042/bj1550487
PMID:949314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172870/
Abstract

The saturation of the delta4-double bond of delta4-3-oxo steroids by the mammalian 5alpha- or 5beta-reductases is by an enzyme mechanism that does not involve a Schiff-base intermediate.

摘要

哺乳动物的5α-或5β-还原酶使δ4-3-氧代类固醇的δ4-双键饱和，其酶促机制不涉及席夫碱中间体。

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本文引用的文献

1
Oxygen-18 exchange reactions in steroidal ketones. Determination of relative rates of incorporation by gas chromatography-mass spectrometry.甾体酮中的氧-18交换反应。通过气相色谱-质谱法测定掺入的相对速率。
Steroids. 1969 Nov;14(5):603-15. doi: 10.1016/s0039-128x(69)80050-4.
2
Factors regulating the metabolism of steroids.调节类固醇代谢的因素。
Vitam Horm. 1967;25:271-314. doi: 10.1016/s0083-6729(08)60038-2.
3
Substrate activation in pyridine nucleotide-linked reactions: illustrations from the steroid field.吡啶核苷酸连接反应中的底物激活：来自类固醇领域的例证
Proc R Soc Lond B Biol Sci. 1972 Feb 15;180(1059):167-77. doi: 10.1098/rspb.1972.0012.
4
The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol.
Eur J Biochem. 1971 Nov 11;23(1):1-6. doi: 10.1111/j.1432-1033.1971.tb01583.x.
5
The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.胆固醇生物合成过程中14,15-双键的形成与还原
Biochem J. 1971 Jan;121(1):131-7. doi: 10.1042/bj1210131.
6
Mechamism and stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5alpha-steroid.δ4-3-氧代甾体转化为3-氧代-5α-甾体的酶促反应机制及立体化学
Eur J Biochem. 1969 Apr;8(3):345-51. doi: 10.1111/j.1432-1033.1969.tb00534.x.
7
Enzymatic conversion of a delta-4-3-ketosteroid into a 3-alpha-hydroxy-5-beta steroid: mechanism and stereochemistry of hydrogen transfer from NADPH. Bile acids and steroids 190.将δ-4-3-酮甾体转化为3-α-羟基-5-β甾体：来自NADPH的氢转移机制和立体化学。胆汁酸与类固醇190
Eur J Biochem. 1967 Nov;2(4):503-7. doi: 10.1111/j.1432-1033.1967.tb00164.x.
8
The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.7-脱氢胆固醇的生物转化及关于双键还原的评论
Biochem J. 1968 Feb;106(4):803-10. doi: 10.1042/bj1060803.
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The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and beta-hydroxybutyrate dehydrogenase.
Biochemistry. 1975 May 20;14(10):2235-41. doi: 10.1021/bi00681a030.