正常和营养不良大鼠大脑脱氧核糖核酸碱基含量随成熟过程的变化
Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats.
作者信息
Penn N W
出版信息
Biochem J. 1976 Jun 1;155(3):709-12. doi: 10.1042/bj1550709.
Abstract
The mol percentage of 5-hydroxymethylcytosine is 2.2 times greater in the adult than in 2-day-old rat brain DNA. The concentration of 5-hydroxymethylcytosine falls in corresponding liver DNA preparations. This normal increase in brain 5-hydroxymethylcytosine is abolished in rats placed on an 8%-protein diet 5 days after birth.
摘要
在成年大鼠大脑DNA中，5-羟甲基胞嘧啶的摩尔百分比比2日龄大鼠大脑DNA中的高2.2倍。在相应的肝脏DNA制剂中，5-羟甲基胞嘧啶的浓度下降。出生后5天给予8%蛋白质饮食的大鼠，大脑中5-羟甲基胞嘧啶的这种正常增加被消除。
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