Nishiharu T, Yamashita Y, Arakawa A, Sumi S, Mitsuzaki K, Matsukawa T, Takahashi M
Department of Radiology, Kumamoto University Hospital, Japan.
Radiology. 1998 Mar;206(3):767-71. doi: 10.1148/radiology.206.3.9494499.
To evaluate the usefulness of helium gas microbubbles in the detection of small hepatocellular carcinoma (HCC) lesions relative to that of CO2 microbubbles.
Ultrasonography (US) enhanced with both CO2 microbubbles and helium microbubbles was performed in 15 patients. CO2 microbubbles were injected into the proper hepatic artery under US observation. Next, helium microbubbles were injected. Duration and degree of enhancement with the two types of microbubbles were compared. Ten minutes after helium injection, the whole liver was examined with US to detect additional tumors. When new lesions were detected, biopsy was performed.
Duration of enhancement with the helium microbubbles (mean, 37.2 minutes) was significantly longer than that with the CO2 microbubbles (mean, 3.6 minutes; P < .001). The degree of enhancement with helium was greater than that with CO2. Thirteen additional lesions were detected after injection of helium gas. All these lesions proved to be HCC at biopsy.
The duration of enhancement is significantly longer with helium than with CO2 microbubbles. Therefore, helium microbubbles can be used for examination of the whole liver for detection of additional tumors.
评估相对于二氧化碳微泡，氦气微泡在检测小肝细胞癌（HCC）病灶中的效用。
对15例患者进行了二氧化碳微泡和氦气微泡增强的超声检查（US）。在超声观察下将二氧化碳微泡注入肝固有动脉。接下来，注入氦气微泡。比较两种微泡的增强持续时间和程度。注入氦气10分钟后，用超声检查全肝以检测其他肿瘤。当检测到新病灶时，进行活检。
氦气微泡的增强持续时间（平均37.2分钟）明显长于二氧化碳微泡（平均3.6分钟；P <.001）。氦气的增强程度大于二氧化碳。注入氦气后检测到13个额外病灶。活检证实所有这些病灶均为HCC。
氦气微泡的增强持续时间明显长于二氧化碳微泡。因此，氦气微泡可用于全肝检查以检测其他肿瘤。
