Moroson H, Schechter M
Biomedicine. 1976 May;25(3):97-100.
Combined radiotherapy and nonspecific adjuvant C. parvum or Piromen treatment of rat tumors show improvement over radiotherapy alone. The most effective protocol, resulting in complete remission in 6 of 6 rats was obtained with C. parvum given i.p. in three doses 1 day prior to tumor X-irradiation of three doses of 1500 R each given on days 1, 4, and 8. Animals receiving the same dose schedule without adjuvant had only partial regression of their tumor. Without adjuvant, increasing the dose to 6000 R also resulted in tumor regression, but at the expense of marked necrosis to the leg. One mechanism for the observed results may be stimulation of the reticulo-endothelial system to produce macrophages activated against the tumor. It is also possible that C. parvum causes increased rate of clearance of soluble antigens released as a result of radiation destruction of the tumor, as suggested by Proctor et al (3).
联合放疗与非特异性佐剂微小隐孢子虫或吡咯烷酮治疗大鼠肿瘤比单纯放疗效果更佳。最有效的方案是在肿瘤进行X线照射前1天腹腔注射微小隐孢子虫，分3剂给药，肿瘤X线照射分别于第1、4和8天各给予3剂，每剂1500伦琴，6只大鼠中有6只实现完全缓解。接受相同剂量方案但无佐剂的动物，其肿瘤仅部分消退。无佐剂时，将剂量增加至6000伦琴也会导致肿瘤消退，但代价是腿部出现明显坏死。观察到的结果的一种机制可能是刺激网状内皮系统产生针对肿瘤的活化巨噬细胞。也有可能如普罗克特等人（3）所指出的，微小隐孢子虫导致因肿瘤辐射破坏而释放的可溶性抗原的清除率提高。
