庚型肝炎病毒感染对肝脏疾病的影响。

Influence of hepatitis G virus infection on liver disease.

作者信息

Diamantis I D, Kouroumalis E, Koulentaki M, Fasler-Kan E, Schmid P A, Hirsch H H, Bühler H, Gyr K, Battegay M

机构信息

Outpatient Department of Internal Medicine, University Hospital Basel, Switzerland.

出版信息

Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):916-9. doi: 10.1007/BF01700559.

DOI:10.1007/BF01700559

PMID:9495673

Abstract

The influence of hepatitis G virus (HGV) infection on disease activity in hepatitis C related and unrelated liver disease was investigated in 254 individuals using an EIA polymerase chain reaction assay for HGV. One hundred patients had chronic hepatitis C, 26 primary biliary cirrhosis, and 30 alcoholic liver cirrhosis. In addition, 51 hepatitis B surface antigen (HBsAg)-positive and 47 anti-hepatitis C virus (HCV)-positive blood donors were screened. Hepatitis G virus was detected in 18% of patients with chronic hepatitis C, 13% of patients with alcoholic liver cirrhosis, 11% of patients with primary biliary cirrhosis, 10% of anti-HCV-positive blood donors, and 2% of HBsAg-positive blood donors. Virus load and alanine aminotransferase (ALT) levels did not differ significantly in patients with HCV alone versus patients coinfected with HCV and HGV. However, mild liver fibrosis correlated with HGV coinfection. Hepatitis G virus did not influence ALT levels or liver damage in liver disease unrelated to viral infection.

摘要

采用酶免疫聚合酶链反应检测法，对254例个体研究了庚型肝炎病毒（HGV）感染对丙型肝炎相关和非相关肝病疾病活动的影响。其中100例为慢性丙型肝炎患者，26例为原发性胆汁性肝硬化患者，30例为酒精性肝硬化患者。此外，对51例乙型肝炎表面抗原（HBsAg）阳性和47例抗丙型肝炎病毒（HCV）阳性的献血者进行了筛查。慢性丙型肝炎患者中18%检测到庚型肝炎病毒，酒精性肝硬化患者中13%检测到，原发性胆汁性肝硬化患者中11%检测到，抗HCV阳性献血者中10%检测到，HBsAg阳性献血者中2%检测到。单纯感染HCV的患者与同时感染HCV和HGV的患者相比，病毒载量和丙氨酸氨基转移酶（ALT）水平无显著差异。然而，轻度肝纤维化与HGV合并感染相关。庚型肝炎病毒对与病毒感染无关的肝病的ALT水平或肝损伤无影响。