Sobel N, Prabhakaran V, Desmond J E, Glover G H, Sullivan E V, Gabrieli J D
Department of Neuroscience, Stanford University, CA 94305, USA. nsobel@leland/stanford.edu
J Neurosci Methods. 1997 Dec 30;78(1-2):115-23. doi: 10.1016/s0165-0270(97)00140-4.
A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings.
描述了一种在功能磁共振成像（fMRI）实验设计中为人类生成嗅觉刺激的方法。该系统包含一个鼻罩，在该鼻罩中，从有气味剂状态到无气味剂状态的转变在不到500毫秒内发生，且不伴有视觉、听觉、触觉或热线索。在长时间存在气味剂之后，该鼻罩提供一个无气味剂的环境。描述了有利于人类嗅觉系统研究的特定成像参数。在使用这些方法进行的一项初步研究中，观察到的激活的特定模式与已发表的实验和临床结果一致。
