Sobel N, Prabhakaran V, Hartley C A, Desmond J E, Zhao Z, Glover G H, Gabrieli J D, Sullivan E V
Program of Neuroscience, Stanford University, Stanford, California, 94305, USA.
J Neurosci. 1998 Nov 1;18(21):8990-9001. doi: 10.1523/JNEUROSCI.18-21-08990.1998.
Functional magnetic resonance imaging was used to test whether odorants induce activation in the cerebellum of the human. The odorants vanillin and propionic acid both induced significant activation, primarily in the posterior lateral hemispheres. Activation was concentration-dependent, greater after stimulation with higher concentration odorants. By contrast, the action of sniffing nonodorized air induced significant activation in the anterior cerebellum, primarily in the central lobule. These findings demonstrate that the cerebellum plays a role in human olfaction. A hypothesis is proposed whereby the cerebellum maintains a feedback mechanism that regulates sniff volume in relation to odor concentration.
功能磁共振成像被用于测试气味剂是否会在人类小脑中诱发激活。香草醛和丙酸这两种气味剂均诱发了显著激活，主要位于后外侧半球。激活呈浓度依赖性，在高浓度气味剂刺激后更为强烈。相比之下，嗅闻无气味空气的动作在前小脑诱发了显著激活，主要位于中央小叶。这些发现表明小脑在人类嗅觉中发挥作用。提出了一个假说，即小脑维持一种反馈机制，该机制根据气味浓度调节嗅吸量。
