Lieber C S
Department of Medicine, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, New York 10468, USA.
J Stud Alcohol. 1998 Jan;59(1):9-25. doi: 10.15288/jsa.1998.59.9.
The medical risks of moderate and excessive alcohol consumption are reviewed. Current knowledge of metabolism of alcohol, including effects of moderate amounts, on hepatic metabolism and toxicity is summarized, with an evaluation of the relationship between the level of consumption and its effects on nutrients (including retinoids, carotenoids and folate), liver disease and other medical complications of alcoholism, including cardiovascular diseases and cancer. Putative benefits are also considered. Promising therapeutic approaches evolving from newly gained insight in the pathogenesis of medical complications of alcoholism are outlined.
本文综述了适度饮酒和过量饮酒的医学风险。总结了目前关于酒精代谢的知识，包括适量饮酒对肝脏代谢和毒性的影响，并评估了饮酒量与其对营养素（包括类视黄醇、类胡萝卜素和叶酸）、肝脏疾病以及酒精中毒的其他医学并发症（包括心血管疾病和癌症）的影响之间的关系。文中还考虑了潜在的益处。概述了从对酒精中毒医学并发症发病机制的新认识中发展而来的有前景的治疗方法。
