麻疹病毒DNA疫苗接种：抗体亚型由免疫方法以及抗原和共同免疫抗原的性质决定。
Measles virus DNA vaccination: antibody isotype is determined by the method of immunization and by the nature of both the antigen and the coimmunized antigen.
作者信息
Cardoso A I, Sixt N, Vallier A, Fayolle J, Buckland R, Wild T F
机构信息
INSERM Unit 404 Immunity and Vaccination, Institut Pasteur de Lyon, France.
出版信息
J Virol. 1998 Mar;72(3):2516-8. doi: 10.1128/JVI.72.3.2516-2518.1998.
Abstract
Plasmids encoding the measles virus hemagglutinin (HA) and nucleoprotein (NP) proteins inoculated into the skin of BALB/c mice by the gene gun method induced both humoral and cytotoxic lymphocyte class I-restricted immune responses. Although intramuscular immunization induces the immunoglobulin G2a (IgG2a) antibody isotype for both antigens, with gene gun immunization, the NP still generated mainly IgG2a and the major isotype induced by the HA was IgG1. Interestingly, gene gun coimmunization of HA and NP plasmids resulted in a dominant IgG1 HA response and the switching of antibodies generated against the NP to the IgG1 isotype.
摘要
通过基因枪方法将编码麻疹病毒血凝素（HA）和核蛋白（NP）蛋白的质粒接种到BALB/c小鼠皮肤中，可诱导体液免疫和细胞毒性淋巴细胞I类限制性免疫反应。尽管肌肉内免疫可诱导针对两种抗原的免疫球蛋白G2a（IgG2a）抗体亚型，但通过基因枪免疫，NP仍主要产生IgG2a，而HA诱导的主要抗体亚型是IgG1。有趣的是，HA和NP质粒的基因枪共免疫导致了占主导地位的IgG1 HA反应，并且针对NP产生的抗体转换为IgG1亚型。
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本文引用的文献
1
Nucleic acid vaccines: an overview.
Vaccine. 1997 Jun;15(8):785-7. doi: 10.1016/s0264-410x(96)00249-6.
2
Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations.基因枪免疫和肌肉注射DNA免疫对靶位点组织的依赖性差异。
J Immunol. 1997 May 15;158(10):4529-32.
3
Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.通过生理盐水和基因枪DNA免疫产生的不同辅助性T细胞类型和抗体亚型。
J Immunol. 1997 Mar 1;158(5):2278-84.
4
5
Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells.通过转染的树突状细胞免疫增强对裸DNA疫苗的免疫反应。
J Leukoc Biol. 1997 Feb;61(2):125-32. doi: 10.1002/jlb.61.2.125.
6
Immunization with plasmid DNA encoding for the measles virus hemagglutinin and nucleoprotein leads to humoral and cell-mediated immunity.用编码麻疹病毒血凝素和核蛋白的质粒DNA进行免疫可产生体液免疫和细胞介导的免疫。
Virology. 1996 Nov 15;225(2):293-9. doi: 10.1006/viro.1996.0603.
7
Functional diversity of helper T lymphocytes.辅助性T淋巴细胞的功能多样性。
Nature. 1996 Oct 31;383(6603):787-93. doi: 10.1038/383787a0.
8
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9
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10
Interleukin-4 causes delayed virus clearance in influenza virus-infected mice.白细胞介素-4导致流感病毒感染小鼠的病毒清除延迟。
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