Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam P P, Monaco A P, Willard H F, Koopman P
Centre for Molecular & Cellular Biology and Department of Anatomical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Hum Mol Genet. 1998 Apr;7(4):737-42. doi: 10.1093/hmg/7.4.737.
We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the mouse X chromosome have been reported previously to escape inactivation. The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice.
我们最近鉴定出一个在小鼠中普遍转录的Y染色体基因Uty，它编码一种四肽重复（TPR）蛋白。源自UTY蛋白的一种肽赋予雄性细胞H-Y抗原性。在此，我们报告了Uty的一个广泛转录的X连锁同源物Utx的特征，该基因定位于小鼠X染色体的近端区域，并在Xp11.2处检测到一个人类X连锁同源物。鉴于Uty是普遍转录的，我们检测了小鼠中失活X染色体（Xi）上Utx的表达，发现Utx逃避了X染色体失活。之前仅报道过小鼠X染色体上的Smcx和假常染色体Sts基因逃避失活。还发现人类UTX基因也从Xi表达。我们讨论了这些数据对于我们理解人类和小鼠中X-Y同源基因剂量补偿的意义。
