Deeks S G
University of California, School of Medicine, San Francisco 94110, USA.
West J Med. 1998 Feb;168(2):133-9.
With the recent development of potent new antiretroviral therapies, the management of HIV infection has become increasingly complex. There are now 12 antiretroviral drugs approved for use in the management of HIV infection, with several more in the advanced stages of clinical development. Staying current with this rapidly changing area of medicine is a challenge to clinicians caring for HIV-infected patients. This review provides an overview of HIV pathogenesis and discusses the basic principles of therapy. These principles, developed recently by the U.S. Department of Health and Human Services, provide a practical framework to rapidly incorporate new developments into clinical practice. Each of the three classes of antiretroviral therapies is then explained, focusing on the practical management of side effects, drug interactions, and viral resistance. The antiviral activity and clinical efficacy of each therapeutic class is reviewed, with an emphasis on applying current results to clinical decision making. Finally, recently published treatment guidelines are reviewed.
随着强效新型抗逆转录病毒疗法的近期发展，HIV感染的管理变得日益复杂。目前有12种抗逆转录病毒药物被批准用于HIV感染的管理，还有几种正处于临床开发的后期阶段。对于照顾HIV感染患者的临床医生而言，紧跟这一快速变化的医学领域是一项挑战。本综述概述了HIV发病机制，并讨论了治疗的基本原则。这些原则由美国卫生与公众服务部近期制定，提供了一个将新进展迅速纳入临床实践的实用框架。然后对三类抗逆转录病毒疗法中的每一类进行了解释，重点关注副作用、药物相互作用和病毒耐药性的实际管理。对每类治疗方法的抗病毒活性和临床疗效进行了综述，重点是将当前结果应用于临床决策。最后，对最近发布的治疗指南进行了综述。
