Vermeulen A, Dhondt M, Thiery M, Vandekerckhove D
Fertil Steril. 1976 Jul;27(7):773-9. doi: 10.1016/s0015-0282(16)41951-5.
The concentrations of sex steroid hormones in plasma were determined daily in 14 young adult women, during both a control cycle and a treatment cycle. During the latter a Silastic ring into which 100 or 200 mg of medroxyprogesterone acetate (Provera) had been incorporated was worn intravaginally. During the treatment cycles, plasma levels of estradiol, progesterone, and 17-hydroxyprogesterone remained within the range observed during the early follicular phase. Testosterone and androstenedione levels did not show any cyclic variation during the treatment cycle; however, the mean levels were decreased by about 25% compared with the over-all plasma levels of the control cycle, whereas dehydroepiandrosterone levels were decreased by about 15%. It is concluded that these Provera-containing Silastic intravaginal rings inhibit ovulation and decrease androgen secretion by the ovaries significantly.
在14名年轻成年女性的一个对照周期和一个治疗周期中，每天测定其血浆中性类固醇激素的浓度。在治疗周期中，她们阴道内佩戴一个已掺入100或200毫克醋酸甲羟孕酮（安宫黄体酮）的硅橡胶环。在治疗周期中，雌二醇、孕酮和17-羟孕酮的血浆水平保持在卵泡早期观察到的范围内。睾酮和雄烯二酮水平在治疗周期中未显示任何周期性变化；然而，与对照周期的总体血浆水平相比，平均水平降低了约25%，而脱氢表雄酮水平降低了约15%。得出的结论是，这些含安宫黄体酮的硅橡胶阴道环可显著抑制排卵并减少卵巢雄激素分泌。
