Valenzuela J E, Walsh J H, Isenberg J I
Gastroenterology. 1976 Sep;71(3):409-11.
This study was designed to assess the effect of unsulfated synthetic human little gastrin (HG-17-I) on pancreatic secretion and gallbladder emptying in man. During continuous gastric and duodenal aspiration, 6 male subjects were given, on different days, either HG-17-I (7, 20, 60, 180 AND 540 PMOL KG-1 HR-1), chlecystokinin (0.1, 0.3, and 0.9 UKg hr-1) or 238 pmol kg-1 (500 ng kg-1) of HG-17-I as a rapid intravenous injection. Trypsin output and bilirubin output increased significantly (P less than 0.05) above basal levels during the infusion of both peptides. During HG-17-I infusion the highest trypsin output (2.08 +/- 0.22 Karmen U per 10 min) and bilirubin output (4.66 +/- 0.61 mg per 10 min) occurred during the 60 pmol kg-1 hr-1 dose, whereas highest acid output occurred during the 540 pmol kg-1 hr-1 dose. Rapid intravenous injection of HG-17-I produced a prompt and significant rise in trypsin, bilirubin, bicarbonate, and acid outputs. It is concluded that HG-17-I produced significant pancreatic enzyme secretion and gallbladder emptying at doses that are submaximal for acid secretion, suggesting that this may be a physiological effect of gastrin.
本研究旨在评估未硫酸化的合成人小胃泌素（HG-17-I）对人体胰腺分泌和胆囊排空的影响。在持续胃和十二指肠抽吸过程中，6名男性受试者在不同日期分别接受HG-17-I（7、20、60、180和540 pmol kg-1 hr-1）、胆囊收缩素（0.1、0.3和0.9 UKg hr-1）或238 pmol kg-1（500 ng kg-1）的HG-17-I快速静脉注射。在两种肽输注期间，胰蛋白酶输出量和胆红素输出量均显著高于基础水平（P<0.05）。在输注HG-17-I期间，60 pmol kg-1 hr-1剂量时胰蛋白酶输出量最高（每10分钟2.08±0.22卡门单位），胆红素输出量最高（每10分钟4.66±0.61毫克），而在540 pmol kg-1 hr-1剂量时胃酸输出量最高。快速静脉注射HG-17-I可使胰蛋白酶、胆红素、碳酸氢盐和胃酸输出量迅速显著增加。得出的结论是，HG-17-I在酸分泌未达到最大值的剂量下可产生显著的胰腺酶分泌和胆囊排空，这表明这可能是胃泌素的一种生理效应。
