Barengolts E I, Berman M, Kukreja S C, Kouznetsova T, Lin C, Chomka E V
University of Illinois, VA West Side Medical Centers, Chicago 60612, USA.
Calcif Tissue Int. 1998 Mar;62(3):209-13. doi: 10.1007/s002239900419.
Estrogen deficiency is a risk factor for osteoporosis and coronary artery disease. Osteoporosis can be evaluated by measuring bone mineral density (BMD). Coronary atherosclerotic burden can be evaluated by measuring coronary calcium using electron beam computed tomography (EBT) of the heart. We compared coronary calcium scores in 45 asymptomatic postmenopausal women with normal and low BMD. BMD of the lumbar spine and proximal femur was measured by dual X-ray absorptiometry (DXA), and coronary calcium was measured quantitatively by EBT. Women were divided into control, osteopenia, and osteoporosis groups based on the T score of the lumbar spine. Women were similar in age, years since menopause, height, weight, and body mass index (BMI). BMD +/- SD (g/cm2) of L1-L4 was 0.96 +/- 0.11, 0.83 +/- 0.03, and 0.73 +/- 0.05, in control, osteopenia, and osteoporosis group, respectively. The total coronary calcium score +/- SD (relative units) was 41.9 +/- 83.1, 115.1 +/- 181.9, and 221.7 +/- 355.4 for control, osteopenia, and osteoporosis group, respectively; the score was significantly higher in the osteoporosis than in the control group. This study provides initial data suggesting that women with osteoporosis may have a higher risk of developing coronary atherosclerosis.
雌激素缺乏是骨质疏松症和冠状动脉疾病的一个风险因素。骨质疏松症可通过测量骨矿物质密度（BMD）来评估。冠状动脉粥样硬化负荷可通过使用心脏电子束计算机断层扫描（EBT）测量冠状动脉钙化来评估。我们比较了45名无症状绝经后女性中骨密度正常和偏低者的冠状动脉钙化评分。腰椎和股骨近端的骨密度通过双能X线吸收法（DXA）测量，冠状动脉钙化通过EBT进行定量测量。根据腰椎的T值将女性分为对照组、骨量减少组和骨质疏松组。这些女性在年龄、绝经年限、身高、体重和体重指数（BMI）方面相似。对照组、骨量减少组和骨质疏松组L1-L4的骨密度±标准差（g/cm2）分别为0.96±0.11、0.83±0.03和0.73±0.05。对照组、骨量减少组和骨质疏松组的冠状动脉钙化总分±标准差（相对单位）分别为41.9±83.1、115.1±181.9和221.7±355.4；骨质疏松组的评分显著高于对照组。这项研究提供了初步数据，表明患有骨质疏松症的女性可能有更高的患冠状动脉粥样硬化的风险。
