Lehman A F, Steinwachs D M
Dept. of Psychiatry, University of Maryland School of Medicine, and Center for Mental Health Services Research, Baltimore, USA.
Schizophr Bull. 1998;24(1):1-10. doi: 10.1093/oxfordjournals.schbul.a033302.
Beginning in 1992, the Agency for Health Care Policy and Research and the National Institute of Mental Health funded the Schizophrenia Patient Outcomes Research Team (PORT) to develop and disseminate recommendations for the treatment of schizophrenia based on existing scientific evidence. These Treatment Recommendations, presented here in final form for the first time, are based on exhaustive reviews of the treatment outcomes literature (previously published in Schizophrenia Bulletin, Vol. 21, No. 4, 1995) and focus on those treatments for which there is substantial evidence of efficacy. The recommendations address antipsychotic agents, adjunctive pharmacotherapies, electroconvulsive therapy, psychological interventions, family interventions, vocational rehabilitation, and assertive community treatment/intensive case management. Support for each recommendation is referenced to the previous PORT literature reviews, and the recommendations are rated according to the level of supporting evidence. The PORT Treatment Recommendations provide a basis for moving toward "evidence-based" practice for schizophrenia and identify both the strengths and limitations in our current knowledge base.
从1992年开始，医疗保健政策与研究机构以及国立精神卫生研究所资助了精神分裂症患者转归研究团队（PORT），以基于现有科学证据制定并传播精神分裂症治疗建议。这些治疗建议首次以最终形式呈现于此，它们基于对治疗转归文献的详尽综述（此前发表于《精神分裂症通报》，第21卷，第4期，1995年），并聚焦于那些有大量疗效证据的治疗方法。这些建议涉及抗精神病药物、辅助药物治疗、电休克治疗、心理干预、家庭干预、职业康复以及积极社区治疗/强化个案管理。每条建议的依据都参考了PORT之前的文献综述，并且根据支持证据的水平对建议进行了评级。PORT治疗建议为迈向精神分裂症的“循证”实践提供了基础，并明确了我们当前知识库中的优势与局限。
