VA Capitol Health care Network (VISN 5) Mental Illness Research, Education, and Clinical Center, Baltimore, MD, USA.
Schizophr Bull. 2010 Jan;36(1):94-103. doi: 10.1093/schbul/sbp130. Epub 2009 Dec 2.
The Schizophrenia Patient Outcomes Research Team (PORT) project has played a significant role in the development and dissemination of evidence-based practices for schizophrenia. In contrast to other clinical guidelines, the Schizophrenia PORT Treatment Recommendations, initially published in 1998 and first revised in 2003, are based primarily on empirical data. Over the last 5 years, research on psychopharmacologic and psychosocial treatments for schizophrenia has continued to evolve, warranting an update of the PORT recommendations. In consultation with expert advisors, 2 Evidence Review Groups (ERGs) identified 41 treatment areas for review and conducted electronic literature searches to identify all clinical studies published since the last PORT literature review. The ERGs also reviewed studies preceding 2002 in areas not covered by previous PORT reviews, including smoking cessation, substance abuse, and weight loss. The ERGs reviewed over 600 studies and synthesized the research evidence, producing recommendations for those treatments for which the evidence was sufficiently strong to merit recommendation status. For those treatments lacking empirical support, the ERGs produced parallel summary statements. An Expert Panel consisting of 39 schizophrenia researchers, clinicians, and consumers attended a conference in November 2008 in which consensus was reached on the state of the evidence for each of the treatment areas reviewed. The methods and outcomes of the update process are presented here and resulted in recommendations for 16 psychopharmacologic and 8 psychosocial treatments for schizophrenia. Another 13 psychopharmacologic and 4 psychosocial treatments had insufficient evidence to support a recommendation, representing significant unmet needs in important treatment domains.
精神分裂症患者结果研究团队（PORT）项目在开发和传播精神分裂症循证实践方面发挥了重要作用。与其他临床指南不同，精神分裂症 PORT 治疗推荐最初于 1998 年发表，2003 年首次修订，主要基于实证数据。在过去的 5 年中，精神分裂症的精神药理学和心理社会治疗研究不断发展，需要更新 PORT 建议。在与专家顾问协商后，两个证据审查小组（ERG）确定了 41 个治疗领域进行审查，并进行了电子文献检索，以确定自上次 PORT 文献综述以来发表的所有临床研究。ERG 还审查了 2002 年以前以前 PORT 审查未涵盖的领域的研究，包括戒烟、药物滥用和体重减轻。ERG 审查了超过 600 项研究，并综合了研究证据，为那些证据足够强值得推荐的治疗方法提出了建议。对于那些缺乏实证支持的治疗方法，ERG 提出了平行的总结陈述。由 39 名精神分裂症研究人员、临床医生和消费者组成的专家小组于 2008 年 11 月参加了一次会议，会上就每个审查治疗领域的证据状况达成了共识。此处介绍了更新过程的方法和结果，为 16 种精神药理学和 8 种心理社会治疗方法推荐了建议。另外 13 种精神药理学和 4 种心理社会治疗方法缺乏支持推荐的证据，这代表了重要治疗领域中未满足的需求。
