葡萄糖氨基乳糖基神经酰胺（氨基CTH-I）作为血型活性糖脂的可能前体存在于人红细胞膜中。

Existence of glucosaminyl lactosyl ceramide (amino CTH-I) in human erythrocyte membranes as a possible precursor of blood group-active glycolipids.

作者信息

Ando S, Kon K, Isobe M, Nagai Y, Yamakawa T

出版信息

J Biochem. 1976 Mar;79(3):625-32. doi: 10.1093/oxfordjournals.jbchem.a131106.

DOI:10.1093/oxfordjournals.jbchem.a131106

Abstract

A novel glycolipid containing N-acetylglucosamine (lacto-N-triose II ceramide, Amino CTH-I) was isolated as a minor component from the ceramide trihexoside fraction of human erythrocyte lipids. This glycolipid was purified by column chromatography and preparative high-speed liquid chromatography on Iatrobeads. Its structure was found to be N-acetylglucosaminyl(beta 1-3)galactosyl(beta 1-4)glucosyl-(beta 1-1)ceramide, so it is suggested that it may be a precursor of paragloboside and blood group-active glycolipids.

摘要

一种含有N-乙酰葡糖胺的新型糖脂（乳糖-N-三糖II神经酰胺，氨基CTH-I）作为次要成分从人红细胞脂质的神经酰胺三己糖苷部分中分离出来。这种糖脂通过柱色谱和在Iatrobeads上的制备型高效液相色谱法进行纯化。发现其结构为N-乙酰葡糖胺基（β1-3）半乳糖基（β1-4）葡糖基-（β1-1）神经酰胺，因此有人提出它可能是副球蛋白和血型活性糖脂的前体。