Caan B J, Coates A O, Slattery M L, Potter J D, Quesenberry C P, Edwards S M
Kaiser Permanente Medical Care Program of Northern California, Division of Research, Oakland 94611, USA.
Int J Obes Relat Metab Disord. 1998 Feb;22(2):178-84. doi: 10.1038/sj.ijo.0800561.
To investigate the risks of height, weight and body fat distribution associated with colon cancer in subcategories of gender, age and site in the colon. Interaction with family history of colorectal cancer is also examined.
Case-control study of diet, anthropometry and colon cancer risk.
Nineteen hundred and eighty-three colon cancer cases (age 30-79 y) and 2400 age and gender matched population controls.
Height, weight and waist and hip circumferences were obtained by trained interviewers. Body Mass Index (BMI) and Waist-Hip Ratio (WHR) were calculated.
Of all anthropometric measurements examined, only BMI was consistently associated with an increased risk of colon cancer. The test for trend for BMI was significant for men and women overall and for the majority of subgroups examined. In younger persons those with a family history of colorectal cancer had a greater risk of colon cancer associated with BMI (Men odds ratio (OR) = 7.76, 95% confidence interval (CI) 2.60, 23.1; Women OR = 4.85, 95% CI 2.33, 10.12) comparing the third tertile to the first, than those with no family history (Men OR = 1.70, 95% CI 1.25, 2.32; Women OR = 1.53, 95% CI 1.22, 1.92). WHR, after controlling for BMI was not associated with colon cancer in men, and was associated with a slight increase in women (primarily in those with distal tumors).
This study contributes to mounting evidence that excess weight is associated with an increased risk of colon cancer.
研究身高、体重和体脂分布在结肠癌患者的性别、年龄及肿瘤部位亚组中的风险。同时也研究与结直肠癌家族史的交互作用。
饮食、人体测量学与结肠癌风险的病例对照研究。
1983例结肠癌患者（年龄30 - 79岁）以及2400例年龄和性别匹配的人群对照。
由经过培训的访员测量身高、体重、腰围和臀围。计算体重指数（BMI）和腰臀比（WHR）。
在所有检测的人体测量指标中，只有BMI始终与结肠癌风险增加相关。总体而言，男性和女性以及大多数检测亚组中，BMI的趋势检验具有显著性。在较年轻人群中，有结直肠癌家族史者与BMI相关的结肠癌风险更高（男性比值比（OR）= 7.76，95%置信区间（CI）2.60，23.1；女性OR = 4.85，95% CI 2.33，10.12），将第三三分位数与第一三分位数相比，高于无家族史者（男性OR = 1.70，95% CI 1.25，2.32；女性OR = 1.53，95% CI 1.22，1.92）。校正BMI后，WHR在男性中与结肠癌无关，而在女性中与结肠癌风险略有增加相关（主要是远端肿瘤患者）。
本研究进一步证明了超重与结肠癌风险增加有关。
