Rössner S
Obesity Unit, Huddinge University Hospital, Sweden.
Int J Obes Relat Metab Disord. 1998 Feb;22(2):190-2. doi: 10.1038/sj.ijo.0800563.
The role of intermittent very low calorie diet (VLCD) in obesity treatment has received little attention. Since such programs can be carried out with limited medical resources, they may offer an additional therapeutic tool. In two studies the effects of 420 or 530 kcal of Nutrilett given daily to 40 and 61 patients [body mass index (BMI) 39.2 +/- 5.1 kg/m2 and 39.0 +/- 5.0 kg/m2, respectively], either continuously for six weeks or for three periods of two weeks with four weeks maintenance interval, were compared. Attrition and weight loss was similar in both groups after 14 and 26 weeks. Intermittent VLCD treatment seems to result in long term weight losses and compliance similar to those obtained by more continuous VLCD therapy. For some individuals less side effects would favour intermittent treatment, for others motivational factors support a more continuous VLCD treatment regimen.
间歇性极低热量饮食（VLCD）在肥胖症治疗中的作用很少受到关注。由于此类方案可以在有限的医疗资源条件下实施，它们可能会提供一种额外的治疗手段。在两项研究中，分别对40名和61名患者（体重指数分别为39.2±5.1kg/m²和39.0±5.0kg/m²）给予每日420千卡或530千卡的纽崔莱，连续六周或分三个两周周期进行，中间间隔四周维持期，比较了两种方式的效果。14周和26周后，两组的损耗和体重减轻情况相似。间歇性VLCD治疗似乎能带来与更持续的VLCD疗法相似的长期体重减轻效果和依从性。对一些人来说，较少的副作用有利于间歇性治疗，而对另一些人来说，动机因素则支持更持续的VLCD治疗方案。
