Hino K, Moriya T, Ohno N, Takahashi K, Hoshino H, Ishiyama N, Katayama K, Yoshizawa H, Mishiro S
Second Department of Internal Medicine, National Defense Medical College, Saitama-ken, Japan.
Arch Virol. 1998;143(1):65-72. doi: 10.1007/s007050050268.
A total of 107 hepatitis C virus (HCV)-infected pregnant women were screened for GB virus C (GBV-C) RNA in their sera, and 11 (10.3%) were positive. Among 11 infants born to these HCV/GBV-C co-infected mothers, GBV-C RNA was detected in 7 (63.6%) while HCV RNA was found in 1 (9.1%) within 1 year after birth: this difference was statistically significant (p = 0.023). The mothers of infected infants had significantly higher serum titers of GBV-C RNA than those of uninfected infants: 10(6.7 +/- 0.5) vs 10(4.0 +/- 1.0) copies/ml in average (p = 0.001). The baby in whom HCV RNA was found was also positive for GBV-C RNA, and had an elevation in serum transaminase levels, whereas all the other GBV-C infected infants showed no evidence for hepatitis. A family study, performed on 2 of the 7 infected cases, revealed that all the elder siblings of the index infants were also GBV-C RNA-positive. Nucleotide sequence of GBV-C RNA, amplified by PCR from an NS3 region, was completely identical between the mother and the infant within each family, but varied significantly across different families. These results suggest that GBV-C is more easily transmitted from mother to infant than HCV, although hepatitis is not caused thereby.
对107名丙型肝炎病毒（HCV）感染的孕妇进行了血清中庚型肝炎病毒（GBV - C）RNA筛查，其中11名（10.3%）呈阳性。在这些HCV/GBV - C合并感染母亲所生的11名婴儿中，出生后1年内7名（63.6%）检测到GBV - C RNA，而1名（9.1%）检测到HCV RNA：这种差异具有统计学意义（p = 0.023）。感染婴儿的母亲血清中GBV - C RNA滴度显著高于未感染婴儿的母亲：平均为10(6.7 +/- 0.5)拷贝/毫升对10(4.0 +/- 1.0)拷贝/毫升（p = 0.001）。检测到HCV RNA的婴儿GBV - C RNA也呈阳性，且血清转氨酶水平升高，而其他所有GBV - C感染婴儿均无肝炎迹象。对7例感染病例中的2例进行的家庭研究显示，索引婴儿的所有年长同胞GBV - C RNA也呈阳性。通过PCR从NS3区域扩增的GBV - C RNA核苷酸序列在每个家庭的母亲和婴儿之间完全相同，但在不同家庭之间差异显著。这些结果表明，GBV - C比HCV更容易从母亲传播给婴儿，尽管不会由此引发肝炎。
