血液系统恶性肿瘤患者中近平滑念珠菌感染的医院内聚集性病例
A nosocomial cluster of Candida inconspicua infections in patients with hematological malignancies.
作者信息
D'Antonio D, Violante B, Mazzoni A, Bonfini T, Capuani M A, D'Aloia F, Iacone A, Schioppa F, Romano F
机构信息
Dipartimento di Ematologia ed Oncologia, Ospedale Santo Spirito, Pescara, Italy.
出版信息
J Clin Microbiol. 1998 Mar;36(3):792-5. doi: 10.1128/JCM.36.3.792-795.1998.
Abstract
Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 microg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.
摘要
从三名血液系统恶性肿瘤患者中分离出了无名假丝酵母菌。两名患者发生了与静脉导管相关的真菌血症，而第三名患者患有真菌性肝炎。这三例感染发生在1个月内，患者住在相邻的单人病房。对真菌菌株进行的体外药敏试验显示，所有分离株对氟康唑耐药，最低抑菌浓度大于32微克/毫升。所有菌株具有相同的DNA限制性图谱和随机扩增多态性DNA指纹。这些数据提示这是一起医院环境中源自共同来源的医院获得性感染。
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