Kroser J A, Faigel D O, Furth E E, Metz D C
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Dig Dis Sci. 1998 Jan;43(1):103-8. doi: 10.1023/a:1018832306135.
Accurate and cost-effective diagnosis of Helicobacter pylori gastritis has taken on major importance. Several serologic tests for the diagnosis of H. pylori infection are commercially available. We compared the performance of the FlexSure HP rapid IgG antibody test with the conventional HM-CAP ELISA to evaluate whether qualitative office-based serology is reliable enough to replace formal laboratory-based testing. We assessed H. pylori status by concordance in 100 consecutive patients with antral biopsy, rapid urease, and 1 microCi[14C]urea breath tests. Both antibody tests had good sensitivity and specificity (>86%). Concordance between the two antibody tests occurred in 87/93 patients (94%). Based on our data, the office-based FlexSure HP performed equally well as the laboratory-based formal ELISA and may be a better choice for initial serologic diagnosis in untreated patients.
准确且经济高效地诊断幽门螺杆菌胃炎具有重要意义。市面上有几种用于诊断幽门螺杆菌感染的血清学检测方法。我们将FlexSure HP快速IgG抗体检测与传统的HM-CAP ELISA的性能进行了比较，以评估基于门诊的定性血清学检测是否足够可靠，足以取代基于正规实验室的检测。我们通过对100例连续进行胃窦活检、快速尿素酶和1微居里[14C]尿素呼气试验的患者进行一致性评估来确定幽门螺杆菌状态。两种抗体检测均具有良好的敏感性和特异性（>86%）。两种抗体检测结果在87/93例患者（94%）中一致。基于我们的数据，基于门诊的FlexSure HP检测与基于实验室的正规ELISA检测表现相当，对于未治疗患者的初始血清学诊断可能是更好的选择。
