Takikawa H, Sano N, Ogasawara T, Yamanaka M
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Dig Dis Sci. 1998 Jan;43(1):188-92. doi: 10.1023/a:1018809028425.
Biliary excretion of lithocholate-3-sulfate and ursodeoxycholate 3,7-disulfate is markedly impaired in EHBR. In the present study, the effects of ursodeoxycholate 3,7-disulfate infusion on lithocholate-3-sulfate excretion were studied in EHBR and Sprague-Dawley rats. Although in control rats, ursodeoxycholate 3,7-disulfate infusion had no effect on biliary lithocholate-3-sulfate excretion, in EHBR it enhanced biliary lithocholate-3-sulfate excretion. Although ursodeoxycholate 3,7-disulfate dose-dependently inhibited lithocholate-3-sulfate binding by rat serum albumin and rat liver cytosol, it did not affect the serum clearance of lithocholate-3-sulfate in EHBR in vivo. These findings indicate that in EHBR, in which the major ATP-dependent organic anion transporter is impaired, the excretory pathway for ursodeoxycholate 3,7-disulfate may interact to that for lithocholate-3-sulfate.
在EHBR中，石胆酸-3-硫酸盐和熊去氧胆酸3,7-二硫酸盐的胆汁排泄明显受损。在本研究中，在EHBR和Sprague-Dawley大鼠中研究了输注熊去氧胆酸3,7-二硫酸盐对石胆酸-3-硫酸盐排泄的影响。虽然在对照大鼠中，输注熊去氧胆酸3,7-二硫酸盐对胆汁石胆酸-3-硫酸盐排泄没有影响，但在EHBR中它增强了胆汁石胆酸-3-硫酸盐的排泄。虽然熊去氧胆酸3,7-二硫酸盐剂量依赖性地抑制大鼠血清白蛋白和大鼠肝细胞溶质对石胆酸-3-硫酸盐的结合，但它在体内对EHBR中石胆酸-3-硫酸盐的血清清除率没有影响。这些发现表明，在主要的ATP依赖性有机阴离子转运体受损的EHBR中，熊去氧胆酸3,7-二硫酸盐的排泄途径可能与石胆酸-3-硫酸盐的排泄途径相互作用。
