Carranza-Lira S, Hernández F, Sánchez M, Murrieta S, Hernández A, Sandoval C
Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico DF. 103144,
Int J Gynaecol Obstet. 1998 Feb;60(2):137-41. doi: 10.1016/s0020-7292(97)00251-8.
To describe the relation between PRL and hCG, T3, T4, fT4, TSH, E2 and P4 levels in normal pregnancies and those complicated with GTD.
Twenty women, 10 with normal pregnancy and 10 with molar pregnancy were studied. The differences between them and the relation between prolactin (PRL) and human chorionic gonadotropin (hCG), estradiol and thyroid hormones, thyroid stimulating hormone (TSH) and progesterone, was determined by Mann-Whitney U-test and Pearson's correlation coefficient, respectively.
HCG, estradiol and thyroid hormones were higher in molar pregnancy, but PRL and progesterone were similar and TSH was lower in molar pregnancy. A negative correlation was found between PRL level and all the hormones in normal pregnancy, with the exception of TSH, and in molar pregnancy there was a positive correlation of PRL with all hormones.
HCG, E2, T3, T4, fT4 levels were higher in the group with molar pregnancy. Differences in correlation analysis suggest different endocrine regulation mechanisms in molar and normal pregnancies.
描述正常妊娠及合并妊娠滋养细胞疾病（GTD）的妊娠中泌乳素（PRL）与绒毛膜促性腺激素（hCG）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离甲状腺素（fT4）、促甲状腺激素（TSH）、雌二醇（E2）和孕酮（P4）水平之间的关系。
对20名女性进行研究，其中10名正常妊娠，10名葡萄胎妊娠。分别采用曼-惠特尼U检验和皮尔逊相关系数来确定她们之间的差异以及泌乳素（PRL）与绒毛膜促性腺激素（hCG）、雌二醇与甲状腺激素、促甲状腺激素（TSH）与孕酮之间的关系。
葡萄胎妊娠中hCG、雌二醇和甲状腺激素水平较高，但PRL和孕酮水平相似，且葡萄胎妊娠中TSH较低。在正常妊娠中，除TSH外，PRL水平与所有激素呈负相关；在葡萄胎妊娠中，PRL与所有激素呈正相关。
葡萄胎妊娠组中hCG、E2、T3、T4、fT4水平较高。相关分析的差异表明葡萄胎妊娠和正常妊娠存在不同的内分泌调节机制。
