Mochizuki M, Morikawa H, Kawaguchi K, Tojo S
J Clin Endocrinol Metab. 1976 Sep;43(3):614-21. doi: 10.1210/jcem-43-3-614.
Twenty patients with molar pregnancy, ten normal pregnant women and ten healthy non-pregnant women were given 30 g of arginine intravenously. The serum concentration of growth hormone, prolactin and chorionic somatomammotropin (CS) was determined by radioimmunoassay. In addition, serum 17beta-estradiol, estriol and progesterone were also measured. Arginine infusion induced a sharp rise of GH in patients with molar pregnancy and in nonpregnant subjects, but the response in normal pregnancy was blunted. The response of PRL was high in patients with molar pregnancy, blunted in normal pregnancy and very small in nonpregnant subjects. CS did not respond at all to arginine infusion both in normal pregnancy and molar pregnancy. The high response to argine of PRL, normal response of GH and low baseline secretion and no response of CS may be characteristic of molar pregnancy.
对20例葡萄胎患者、10例正常孕妇和10例健康非孕妇静脉注射30克精氨酸。采用放射免疫分析法测定生长激素、催乳素和绒毛膜生长催乳素（CS）的血清浓度。此外，还测定了血清17β-雌二醇、雌三醇和孕酮。精氨酸输注导致葡萄胎患者和非妊娠受试者的GH急剧升高，但正常妊娠时的反应减弱。葡萄胎患者的PRL反应较高，正常妊娠时反应减弱，非妊娠受试者反应非常小。正常妊娠和葡萄胎妊娠时CS对精氨酸输注均无反应。PRL对精氨酸的高反应、GH的正常反应、低基线分泌以及CS无反应可能是葡萄胎妊娠的特征。
