Girman C J, Jacobsen S J, Tsukamoto T, Richard F, Garraway W M, Sagnier P P, Guess H A, Rhodes T, Boyle P, Lieber M M
Department of Epidemiology, Merck Research Laboratories, West Point, Pennsylvania, USA.
Urology. 1998 Mar;51(3):428-36. doi: 10.1016/s0090-4295(97)00717-6.
To describe health-related quality of life (HRQL) associated with lower urinary tract symptoms (LUTS) assessed by validated questionnaires in four countries.
More than 6000 men, recruited by using community- or population-based sampling in four countries, completed questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities, and other measures of HRQL.
In all countries, disease-specific HRQL worsened with increasing age. Adjusting for age, most disease-specific HRQL measures were significantly worse with increasing symptom severity. The correlation between symptoms and HRQL was strongest in countries with higher prevalence of symptoms, such as Japan or the United States, and less pronounced in countries with lower prevalence (France, Scotland), possibly reflecting the lower variability in scores.
HRQL measures are worse in older men, and increased urinary symptom severity is associated with worse disease-specific HRQL in all countries, despite potential cross-cultural differences in disease prevalence, medication use, perceptions, or willingness to report symptoms or worse HRQL. This cross-cultural consistency suggests that an assessment of symptom bother or interference with daily activities may be useful in patient evaluation.
通过在四个国家使用经过验证的问卷评估与下尿路症状（LUTS）相关的健康相关生活质量（HRQL）。
在四个国家通过社区或人群抽样招募了6000多名男性，他们完成了问卷，这些问卷收集了有关排尿症状频率、困扰程度、对日常活动的干扰程度以及其他HRQL指标的信息。
在所有国家，特定疾病的HRQL都随着年龄的增长而恶化。在调整年龄后，大多数特定疾病的HRQL指标随着症状严重程度的增加而显著变差。症状与HRQL之间的相关性在症状患病率较高的国家（如日本或美国）最强，而在患病率较低的国家（法国、苏格兰）则不太明显，这可能反映了得分的变异性较低。
老年男性的HRQL指标较差，并且在所有国家，排尿症状严重程度的增加都与特定疾病的HRQL较差有关，尽管在疾病患病率、药物使用、认知或报告症状或较差HRQL的意愿方面可能存在跨文化差异。这种跨文化的一致性表明，评估症状困扰或对日常活动的干扰可能对患者评估有用。
