Sagnier P P, MacFarlane G, Teillac P, Botto H, Richard F, Boyle P
Epidemiology Department, Merck Research Laboratories, C.H.U. Saint-Louis, Paris, France.
J Urol. 1995 Mar;153(3 Pt 1):669-73. doi: 10.1097/00005392-199503000-00033.
The impact of symptoms of prostatism on level of bother and quality of life of French men was assessed nationwide, in a representative community sample of 2,011 subjects 50 to 84 years old. Bothersome level and quality of life associated with 12 urinary symptoms were assessed by face-to-face interviews, using a previously validated questionnaire for benign prostatic hyperplasia (BPH). The international prostate symptom score and the American Urological Association (AUA) bothersome index were also computed. Urgency was by far the most bothersome symptom in French men. Nocturia and wetting underclothes ranked second in subjects who did not undergo prostate surgery and among symptomatic patients, respectively. Overall, symptom frequency accounted for 72% of the variability of symptom bother but the form and strength of this correlation varied among symptoms from 0.18 to 0.43. Among the symptomatic subjects who had not yet undergone prostate surgery 11%, 10% and 79%, respectively, were dissatisfied, neutral and satisfied with the current urinary condition. Satisfaction with the urinary condition was positively linked to symptom frequency (p < 0.001) and symptom bother level (p < 0.001). Nocturia, dysuria, daytime repeat voiding, wetting clothes and urgency, when severely bothersome, were independent predictors of decreased satisfaction with the urinary condition (p = 0.01). Approximately half of the patients with severe BPH symptoms expressed serious worries and concerns with the urinary condition, and sizable levels of interference by the symptoms with daily activities, which are potentially affected by urinary troubles. The AUA bother index was the best determinant of subject level of worry about the urinary condition and of interference with daily life. This study supported the concomitant use of the international prostate symptom score and the AUA bother index in further research studies of BPH related impairments in quality of life.
在全国范围内，对年龄在50至84岁的2011名具有代表性的社区受试者进行了前列腺增生症状对法国男性困扰程度和生活质量影响的评估。通过面对面访谈，使用先前验证过的良性前列腺增生（BPH）问卷，评估了与12种泌尿系统症状相关的困扰程度和生活质量。还计算了国际前列腺症状评分和美国泌尿外科学会（AUA）困扰指数。尿急是法国男性中最困扰人的症状。夜尿症和弄湿内衣分别在未接受前列腺手术的受试者和有症状的患者中排名第二。总体而言，症状频率占症状困扰变异性的72%，但这种相关性的形式和强度在不同症状之间从0.18到0.43不等。在尚未接受前列腺手术的有症状受试者中，分别有11%、10%和79%对当前的泌尿状况不满意、持中立态度和满意。对泌尿状况的满意度与症状频率（p < 0.001）和症状困扰程度（p < 0.001）呈正相关。当夜尿症、排尿困难、白天反复排尿、弄湿衣服和尿急严重困扰时，是对泌尿状况满意度降低的独立预测因素（p = 0.01）。大约一半有严重BPH症状的患者对泌尿状况表示严重担忧，症状对日常活动有相当程度的干扰，而这些日常活动可能受到泌尿系统问题的影响。AUA困扰指数是受试者对泌尿状况担忧程度和对日常生活干扰的最佳决定因素。这项研究支持在进一步研究BPH相关生活质量损害时同时使用国际前列腺症状评分和AUA困扰指数。
