Lewis S J, Oakey R E, Heaton K W
University Department of Medicine, Bristol Royal Infirmary, UK.
Eur J Gastroenterol Hepatol. 1998 Jan;10(1):33-9. doi: 10.1097/00042737-199801000-00007.
The mechanism by which a high fibre diet may reduce serum oestrogens is unknown. We hypothesized that time is a rate-limiting factor in oestrogen absorption from the colon so that changes in colonic transit-rate affect the proportion of oestrogen that is deconjugated and/or absorbed.
To determine if alteration of intestinal transit rate would influence the absorption of an oral dose of oestradiol glucuronide.
Twenty healthy postmenopausal women recruited by advertisement.
Department of Medicine, Bristol Royal Infirmary.
Volunteers consumed, in turn, wheat bran, senna, loperamide and bran shaped plastic flakes, each for 10 days with a minimum 2 week washout period between study periods, dietary intake being unchanged. Before and in the last 4 days of each intervention whole-gut transit-time, defecation frequency, stool form, stool beta-glucuronidase activity, stool pH and the absorption of a 1.5 mg dose of oestradiol glucuronide were measured.
Wheat bran, senna and plastic flakes led to the intended reduction in whole-gut transit-time, increase in defecatory frequency and increase in stool form score. Loperamide caused the opposite effect. The length of time the absorbed oestrogen was detectable in the serum fell with wheat bran and senna, although this was only significant for oestradiol. Oestrone, but not oestradiol, was detectable for a longer time with loperamide. Plastic flakes had no effect on either oestrogen. Areas under the curve did not change significantly but tended to fall with the three transit-accelerating agents and to rise with loperamide.
Our data indicate there is likely to be an effect of intestinal transit on the absorption of oestrogens but more refined techniques are needed to characterize this properly.
高纤维饮食降低血清雌激素的机制尚不清楚。我们推测时间是雌激素从结肠吸收的限速因素，因此结肠转运速率的变化会影响雌激素去结合和/或吸收的比例。
确定肠道转运速率的改变是否会影响口服剂量的雌二醇葡糖苷酸的吸收。
通过广告招募的20名健康绝经后女性。
布里斯托尔皇家医院医学部。
志愿者依次食用麦麸、番泻叶、洛哌丁胺和麸皮形状的塑料片，每种食用10天，研究期间之间至少有2周的洗脱期，饮食摄入量不变。在每次干预前和最后4天测量全肠道转运时间、排便频率、粪便形态、粪便β-葡糖醛酸酶活性、粪便pH值以及1.5毫克剂量的雌二醇葡糖苷酸的吸收情况。
麦麸、番泻叶和塑料片导致全肠道转运时间如预期减少，排便频率增加，粪便形态评分增加。洛哌丁胺产生相反的效果。血清中可检测到吸收的雌激素的时间长度随麦麸和番泻叶而缩短，尽管这仅对雌二醇有显著意义。使用洛哌丁胺时，雌酮而非雌二醇可在更长时间内被检测到。塑料片对两种雌激素均无影响。曲线下面积没有显著变化，但倾向于随三种加速转运的药物而下降，随洛哌丁胺而上升。
我们的数据表明肠道转运可能对雌激素的吸收有影响，但需要更精细的技术来恰当地描述这一现象。
