Cai P, Smith D, Cunningham B, Brown-Shimer S, Katz B, Pearce C, Venables D, Houck D
MYCOsearch, a subsidiary of OSI Pharmaceuticals, 4727 University Drive, Suite 400, Durham, North Carolina 27707, USA.
J Nat Prod. 1999 Feb;62(2):397-9. doi: 10.1021/np980450t.
In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 microM, which is about threefold greater potency than our previously identified erythropoietin inducers.
在筛选促红细胞生成素基因表达的小分子调节剂过程中，从OS-F61800培养物中分离出一种新型N-羟基吡啶酮。通过广泛的1H和13C NMR光谱及化学研究阐明了其结构。该化合物在浓度为0.3 microM时可诱导促红细胞生成素基因表达增加五倍，其效力比我们之前鉴定的促红细胞生成素诱导剂约高两倍。
