水痘带状疱疹病毒的分子生物学。为英国水痘咨询小组撰写的一篇综述

Molecular biology of varicella-zoster virus. A review prepared for the UK Advisory Group on Chickenpox.

作者信息

Harper D R, Gilbert R L, Jeffries D J

机构信息

Department of Virology, St Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, London, UK.

出版信息

J Infect. 1998 Jan;36 Suppl 1:1-10. doi: 10.1016/s0163-4453(98)80149-7.

DOI:10.1016/s0163-4453(98)80149-7

PMID:9514102

Abstract

Varicella-zoster virus (human herpesvirus 3; VZV) is one of eight herpes viruses that routinely infect humans. It is classified as a member of the genus Varicellovirus, subfamily Alphaherpesvirinae, family Herpesviridae. Of the other human herpes viruses it is most closely related to the herpes simplex viruses (also members of the Alphalerpesvirinae). Like all herpes viruses, the virus has a large double-stranded DNA genome within an icosahedral nucleocapsid. This is surrounded by a proteinaceous tegument and a trilaminar membrane derived from host-cell membranes into which the viral glycoproteins are inserted. The structure of the virion is summarized in Fig. 1.

摘要

水痘带状疱疹病毒（人疱疹病毒3型；VZV）是八种通常感染人类的疱疹病毒之一。它被归类为水痘病毒属、α疱疹病毒亚科、疱疹病毒科的成员。在其他人类疱疹病毒中，它与单纯疱疹病毒（也是α疱疹病毒亚科的成员）关系最为密切。与所有疱疹病毒一样，该病毒在二十面体核衣壳内有一个大型双链DNA基因组。它被一层蛋白质衣壳和一层源自宿主细胞膜的三层膜包围，病毒糖蛋白插入该膜中。病毒粒子的结构总结于图1。