Tissandier O, Péres G, Fiet J, Piette F
Service de Physiologie et médecine du Sport, Hôpital Pitié-Salpétrière, Paris, France.
Eur J Appl Physiol. 2001 Jul;85(1-2):177-84. doi: 10.1007/s004210100420.
The influence of physical activity on dehydroepiandrosterone sulfate (DHEAS), total and free testosterone (TT and FT, respectively), insulin-like growth factor I (IGF-1), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and insulin concentrations in aging men was investigated. Eight trained and nine sedentary men aged 60-65 years volunteered to participate in this study. Physical activity was determined during an effort test and evaluated by the measure of the maximal aerobic power (W(aer,max)). In the trained aging men, the W(aer,max) was higher than in the sedentary group of matching age [mean (SD) 206.8 (17.1) W versus 136.6 (12.3) W; P<0.0001]. The fat percentage was higher in the sedentary (n = 9) than in the trained (n = 8) group [23.9 (3.2)% versus 14.6 (3.7)%; P<0.0001]. DHEAS and IGF-1 levels were higher in trained than in sedentary subjects, respectively 2.04 (1) micromol/l versus 1.01 (0.68) micromol/l (P=0.02) and 192.1 (40.1) ng/ml versus 132.8 (31.2) ng/ml (P= 0.003). Insulin levels were higher in sedentary subjects [11.2 (3.5) mIU/l versus 7.6 (2.2) mIU/l, P=0.03]. No statistical difference was observed between both groups for FT and total TT values, FSH values and LH values. IGF-1 was correlated with W(aer,max) (r = 0.64, P = 0.003), and DHEAS was correlated with IGF-1 (r=0.59, P=0.01). We observed a relationship between fat percentage and each of the following hormones: IGF-1 (r=-0.50, P=0.03), FT (r=-0.66, P= 0.002), TT (r=-0.54, P = 0.02) and insulin (r=0.63, P=0.004). Insulin was inversely correlated with FT (r= -0.66, P=0.002) and TT (r=-0.47, P=0.05). These results suggest that regular physical activity could maintain higher DHEAS and IGF-1 and lean body mass levels in elderly men, and participate in general well being in older age.
研究了体育活动对老年男性硫酸脱氢表雄酮（DHEAS）、总睾酮和游离睾酮（分别为TT和FT）、胰岛素样生长因子I（IGF-1）、促卵泡激素（FSH）、黄体生成素（LH）和胰岛素浓度的影响。8名受过训练的和9名久坐不动的60 - 65岁男性自愿参与本研究。体育活动通过一项耐力测试来测定，并通过最大有氧功率（W(aer,max)）的测量进行评估。在受过训练的老年男性中，W(aer,max)高于相匹配年龄的久坐组[均值（标准差）206.8（17.1）瓦对136.6（12.3）瓦；P<0.0001]。久坐组（n = 9）的体脂百分比高于受过训练组（n = 8）[23.9（3.2）%对14.6（3.7）%；P<0.0001]。受过训练的受试者的DHEAS和IGF-1水平分别高于久坐不动的受试者，分别为2.04（1）微摩尔/升对1.01（0.68）微摩尔/升（P = 0.02）和192.1（40.1）纳克/毫升对132.8（31.2）纳克/毫升（P = 0.003）。久坐不动的受试者胰岛素水平更高[11.2（3.5）毫国际单位/升对7.6（2.2）毫国际单位/升，P = 0.03]。两组在FT和总TT值、FSH值和LH值方面未观察到统计学差异。IGF-1与W(aer,max)相关（r = 0.64，P = 0.003），DHEAS与IGF-1相关（r = 0.59，P = 0.01）。我们观察到体脂百分比与以下每种激素之间存在关系：IGF-1（r = -0.50，P = 0.03）、FT（r = -0.66，P = 0.002）、TT（r = -0.54，P = 0.02）和胰岛素（r = 0.63，P = 0.004）。胰岛素与FT（r = -0.66，P = 0.002）和TT（r = -0.47，P = 0.05）呈负相关。这些结果表明，规律的体育活动可以使老年男性维持较高的DHEAS和IGF-1水平以及瘦体重水平，并有助于老年人的总体健康。
