Ogle C W, Turner P, Markomihelakis H
Psychopharmacologia. 1976 Apr 15;46(3):295-9. doi: 10.1007/BF00421117.
The effects of oral oxprenolol (320 mg) or propranolol (240 or 320 mg) and of diazepam (5 mg) or lorazepam (2 mg) on pursuit rotor performance, reaction time and critical flicker frequency were investigated in healthy subjects in 3 separate studies. A 240-mg dose of propranolol significantly impaired pursuit rotor performance but not 320 mg of propranolol or oxprenolol. Both beta-adrenoceptor blockers did not affect reaction time or critical flicker frequency. Diazepam impaired pursuit rotor performance and reaction time, but not critical flicker frequency. Lorazepam generally impaired all three parameters. The findings suggest that it is possible for beta-adrenoceptor blockers to depress skeletal muscle activity without having a central effect, as shown by impairment of CNS function tests which rely also on muscle coordination but not of those relying only on central activity. These results also show that single oral doses of oxprenolol or propranolol, as high as 320 mg, do not have central effects, and support the belief that small anxiolytic doses of these blockers exert their actions through peripheral blockade of beta-adrenoceptors.
在三项独立研究中，对健康受试者口服氧烯洛尔（320毫克）或普萘洛尔（240或320毫克）以及地西泮（5毫克）或劳拉西泮（2毫克）对追踪转子性能、反应时间和临界闪烁频率的影响进行了研究。240毫克剂量的普萘洛尔显著损害追踪转子性能，但320毫克的普萘洛尔或氧烯洛尔则没有。两种β-肾上腺素能受体阻滞剂均不影响反应时间或临界闪烁频率。地西泮损害追踪转子性能和反应时间，但不影响临界闪烁频率。劳拉西泮通常会损害所有这三个参数。研究结果表明，β-肾上腺素能受体阻滞剂有可能在不产生中枢作用的情况下抑制骨骼肌活动，这表现为依赖肌肉协调的中枢神经系统功能测试受到损害，但仅依赖中枢活动的测试则未受影响。这些结果还表明，高达320毫克的单次口服剂量的氧烯洛尔或普萘洛尔没有中枢作用，并支持这样一种观点，即这些阻滞剂的小剂量抗焦虑作用是通过外周β-肾上腺素能受体阻滞发挥的。
