Institute of Psychiatry, De Crespigny Park, Denmark Hill, London.
Br J Clin Pharmacol. 1974 Oct;1(5):387-90. doi: 10.1111/j.1365-2125.1974.tb00274.x.
1 Twelve chronically anxious psychiatric out-patients, comprising six with somatic anxiety and six with psychic anxiety, were treated with (±)-propranolol, diazepam and placebo for one week each in flexible dosage using a balanced cross-over experimental design. 2 After each treatment, in addition to ratings completed by patient and psychiatrist, finger tremor, EEG, averaged auditory evoked response, skin conductance, heart and respiratory rate were measured. 3 Diazepam significantly increased the amount of fast activity (13.5-26 Hz) in the EEG but produced few peripheral effects apart from a reduction in finger tremor. 4 Propranolol had no central physiological effects but reduced both pulse rate and finger tremor. 5 The physiological effects of propranolol in chronic anxiety are different from those of diazepam and therapeutic benefit appears to be due to a direct effect on certain somatic symptoms.
12 名慢性焦虑症门诊患者，包括 6 名躯体焦虑症患者和 6 名精神焦虑症患者，采用灵活剂量的平衡交叉实验设计，分别接受（±）-心得安、安定和安慰剂治疗一周。
每次治疗后，除了患者和精神科医生的评分外，还测量了手指震颤、脑电图、平均听觉诱发电位、皮肤电导、心率和呼吸率。
安定显著增加了脑电图中的快活动（13.5-26 Hz），但除了降低手指震颤外，几乎没有产生其他外周效应。
心得安对中枢生理没有影响，但降低了脉搏率和手指震颤。
心得安在慢性焦虑症中的生理作用与安定不同，治疗效果似乎是由于对某些躯体症状的直接作用。
