Morotome Y, Goseki-Sone M, Ishikawa I, Oida S
Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
Biochem Biophys Res Commun. 1998 Mar 6;244(1):85-90. doi: 10.1006/bbrc.1998.8213.
Growth and differentiation factors (GDF)-5, -6, and -7 are members of the bone morphogenetic protein (BMP) family. Previous studies suggest their importance in bone development and in tendon/ligament morphogenesis. The cells of the dental attachment apparatus, cementum, periodontal ligament, and alveolar bone proper are derived from the dental follicle proper. In this study, we investigated the expression of GDF-5, -6, and -7 genes in tissues of the bovine incisor tooth germ at the root forming stage. The results demonstrate distinct expression of GDFs in both the dental follicle and the odontoblast layer. While GDF-5 and -6 mRNAs were expressed in both the dental follicle and the odontoblast layer, GDF-7 mRNA expression was detected only in the dental follicle. These results indicate that GDFs, expressed in the bovine tooth germ including the dental follicle, may be potent regulatory molecules in the development of the dental attachment apparatus.
生长分化因子（GDF）-5、-6和-7是骨形态发生蛋白（BMP）家族的成员。先前的研究表明它们在骨骼发育以及肌腱/韧带形态发生中具有重要作用。牙齿附着装置的细胞，即牙骨质、牙周韧带和固有牙槽骨，均源自固有牙囊。在本研究中，我们调查了牛切牙牙胚在牙根形成阶段组织中GDF-5、-6和-7基因的表达情况。结果表明，GDF在牙囊和成牙本质细胞层中均有不同的表达。虽然GDF-5和-6的mRNA在牙囊和成牙本质细胞层中均有表达，但仅在牙囊中检测到GDF-7的mRNA表达。这些结果表明，在包括牙囊在内的牛牙胚中表达的GDF可能是牙齿附着装置发育过程中的有效调节分子。
