Goto Y, Toyota T, Masuda M, Komatsu K, Kuriki A
Tohoku J Exp Med. 1976 Jun;119(2):135-48. doi: 10.1620/tjem.119.135.
Age and sex distribution of diabetics, seasonal incidence of diabetes, grade of hyperglycemia, frequency of vascular complications and daily living conditions were studied of 2771 diabetic patients experienced at five clinics. The cases consisted of 1587 male and 1184 female diabetics. The distribution of age of diabetes onset revealed that males predominate among diabetics but females predominate among child diabetics, and that the precentage of child was extremely low. This pattern was emphasized as characteristic of Japanese diabetic population. Distribution of fasting blood sugar at the diagnosis of diabetes was compared among the age groups of diabetes-onset and the results showed that percentage of the value exceeding 300 mg/100 ml was highest in the under 10 year-onset cases and decreased with age. The frequency of diabetic retinopathy and of ischemic ECG changes was analysed from the view point of age of diabetes onset and also the duration of the disease. The frequency of the retinopathy at the diabetes-onset was zero in the under 10 year-onset cases, 4.2% in the 10s-onset cases and increased with age. The longer the duration of the disease the higher the frequency of the retinopathy was. This increase along with the duration was most remarkable in the 10s- and 20s-onset cases and less remarkable in the 30s-onset cases. The retinopathy was significantly more frequent in female diabetics. Daily of the patients were studied by a questionnaire and the analysis of 1022 cases with diabetes of more than three years revealed that cases of patients working uneventfully and/or feeling fit were most frequent among the 30s- or 40s-onset cases and that cases of bed-disability were frequent among the cases whose diabetes was found in their twenties or younger. This study showed that the prognosis of the patients is quite different according to whether their diabetes occurred before of after 30 years of age.
对在五家诊所就诊的2771例糖尿病患者的年龄、性别分布、糖尿病的季节性发病率、高血糖程度、血管并发症发生率及日常生活状况进行了研究。病例包括1587例男性糖尿病患者和1184例女性糖尿病患者。糖尿病发病年龄分布显示，糖尿病患者中男性占主导，但儿童糖尿病患者中女性占主导，且儿童患者的比例极低。这种模式被强调为日本糖尿病患者群体的特征。比较了不同糖尿病发病年龄组在糖尿病诊断时的空腹血糖分布情况，结果显示，发病年龄在10岁以下的患者中，血糖值超过300mg/100ml的比例最高，且随年龄增长而降低。从糖尿病发病年龄和病程的角度分析了糖尿病视网膜病变和缺血性心电图改变的发生率。发病年龄在10岁以下的患者中，糖尿病发病时视网膜病变的发生率为零，发病年龄在10多岁的患者中为4.2%，且随年龄增长而增加。病程越长，视网膜病变的发生率越高。这种随病程的增加在发病年龄在10多岁和20多岁的患者中最为显著，在发病年龄在30多岁的患者中则不太显著。女性糖尿病患者中视网膜病变的发生率明显更高。通过问卷调查研究了患者的日常生活情况，对1022例病程超过三年的糖尿病患者的分析显示，发病年龄在30多岁或40多岁的患者中，工作平稳和/或感觉良好的患者最为常见，而在20岁或更年轻时被发现患有糖尿病的患者中，卧床残疾的患者较为常见。这项研究表明，根据糖尿病是在30岁之前还是之后发生，患者的预后有很大不同。
