纤维肌痛综合征患者的褪黑素水平正常。
Normal melatonin levels in patients with fibromyalgia syndrome.
作者信息
Press J, Phillip M, Neumann L, Barak R, Segev Y, Abu-Shakra M, Buskila D
机构信息
Epidemiology Department, Ben-Gurion University of the Negev and Soroka Medical Center, Beer Sheva, Israel.
出版信息
J Rheumatol. 1998 Mar;25(3):551-5.
OBJECTIVE
To assess urine levels of melatonin measured by 6-sulphatoxymelatonin (aMT6s) in patients with fibromyalgia (FM).
METHODS
Nocturnal aMT6s urine levels were measured by ELISA, in a sample of urine collected from 10 PM to 7 AM from 39 female patients with FM and 39 age matched healthy female controls. All subjects were interviewed and assessed for nonarticular tenderness, FM symptoms, quality of life, and physical functioning.
RESULTS
Nocturnal aMT6s levels of patients with FM were not statistically different from those of controls: 16.7+/-9.2 vs 16.0+/-11.3 microg, respectively. No association was observed between aMT6s levels of patients with FM and disease duration, reproductive status, sleep and mood disturbances.
CONCLUSION
Nocturnal urine aMT6s levels were similar in patients with FM and controls. Studies are needed to elucidate the possible role of melatonin in FM and should include larger samples of newly diagnosed untreated patients with FM.
目的
评估通过6-硫酸氧褪黑素（aMT6s）测定的纤维肌痛（FM）患者尿液中褪黑素水平。
方法
采用酶联免疫吸附测定法（ELISA）测量夜间aMT6s尿液水平，尿液样本采集自39例女性FM患者以及39例年龄匹配的健康女性对照，采集时间为晚上10点至次日早上7点。对所有受试者进行访谈，并评估非关节压痛、FM症状、生活质量和身体功能。
结果
FM患者的夜间aMT6s水平与对照组无统计学差异：分别为16.7±9.2与16.0±11.3微克。未观察到FM患者的aMT6s水平与疾病持续时间、生殖状态、睡眠和情绪障碍之间存在关联。
结论
FM患者与对照组的夜间尿液aMT6s水平相似。需要开展研究以阐明褪黑素在FM中的可能作用，且研究应纳入更大样本的新诊断未治疗的FM患者。
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