Naarendorp M, Spiera H
Department of Medicine, Mount Sinai Medical Center, New York, NY 10029-6574, USA.
J Rheumatol. 1998 Mar;25(3):589-92.
Although the pathogenesis of sudden sensorineural hearing loss (SNHL) in patients with systemic lupus erythematosus (SLE) is not clear, several reports suggest an association with the antiphospholipid antibody (aPL). We describe 6 patients with SLE or a lupus-like syndrome, who had sudden SNHL and had elevated levels of anticardiolipin antibodies (aCL) or the lupus anticoagulant. In a literature search, of 5 additional reported cases, 2 were not tested for aPL; the remaining 3 had elevated aCL levels. Thus, acute SNHL in patients with SLE who have aPL may be a manifestation of the antiphospholipid syndrome. We recommend anticoagulation treatment of these patients.
尽管系统性红斑狼疮（SLE）患者突发感音神经性听力损失（SNHL）的发病机制尚不清楚，但有几份报告表明其与抗磷脂抗体（aPL）有关。我们描述了6例患有SLE或狼疮样综合征的患者，他们突发SNHL，且抗心磷脂抗体（aCL）水平或狼疮抗凝物升高。在文献检索中，另外报告的5例病例中，2例未检测aPL；其余3例aCL水平升高。因此，患有aPL的SLE患者急性SNHL可能是抗磷脂综合征的一种表现。我们建议对这些患者进行抗凝治疗。
