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1
What is Zelen's design?什么是泽伦设计？
BMJ. 1998 Feb 21;316(7131):606. doi: 10.1136/bmj.316.7131.606.
2
[Reappraisal of Zelen's method in randomized controlled trials].[随机对照试验中泽伦方法的重新评估]
Gan To Kagaku Ryoho. 1992 Oct;19(12):1953-7.
3
The use of Zelen's design in randomised trials.
BJOG. 2004 Jan;111(1):2. doi: 10.1111/j.1471-0528.2004.00033.x.
4
Informed consent. Trials that use Zelen's procedure should be acceptable.知情同意。采用泽伦程序的试验应该是可以接受的。
BMJ. 1997 Jul 26;315(7102):251.
5
[n or more in clinical trials? Zelen's models for randomization].
Lakartidningen. 1994 Mar 9;91(10):977-82.
6
Randomization and efficiency in Zelen's single-consent design.泽伦单同意书设计中的随机化与效率
Biometrics. 1987 Dec;43(4):885-94.
7
Review of randomised trials using the post-randomised consent (Zelen's) design.使用随机后同意（泽伦氏）设计的随机试验综述。
Contemp Clin Trials. 2006 Aug;27(4):305-19. doi: 10.1016/j.cct.2005.11.003. Epub 2006 Feb 7.
8
Adaptive designs, informed consent, and the ethics of research.适应性设计、知情同意与研究伦理
Control Clin Trials. 2001 Jun;22(3):203-10. doi: 10.1016/s0197-2456(01)00122-2.
9
Validity and treatment dilution in Zelen's single consent design.
Stat Med. 1984 Jul-Sep;3(3):215-8. doi: 10.1002/sim.4780030303.
10
Recruitment in Clinical Trials: The Use of Zelen's Prerandomization in Recent Neurovascular Studies.临床试验中的招募：Zelen预随机化方法在近期神经血管研究中的应用
World Neurosurg. 2017 Feb;98:403-410. doi: 10.1016/j.wneu.2016.11.052. Epub 2016 Nov 19.

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An Incognito Standardized Patient Approach for Measuring and Reducing Intersectional Healthcare Stigma: A Pilot Cluster Randomized Control Trial.一种用于测量和减少交叉性医疗耻辱感的隐匿标准化患者方法：一项试点整群随机对照试验。
J Acquir Immune Defic Syndr. 2025 Mar 1;98(3):224-233. doi: 10.1097/QAI.0000000000003565. Epub 2025 Feb 5.
2
Techniques for randomization and allocation for clinical trials.临床试验的随机化和分配技术。
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FIT as a Comparator for Evaluating the Effectiveness of New Non-invasive CRC Screening Test.粪便免疫化学检测（FIT）作为评估新型非侵入性结直肠癌筛查试验有效性的对照物
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Registry-based randomised controlled trials: conduct, advantages and challenges-a systematic review.基于注册的随机对照试验：实施、优势和挑战——系统评价。
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5
Efficacy and safety comparison of infrared laser moxibustion and traditional moxibustion in knee osteoarthritis: study protocol for a Zelen-design randomized controlled non-inferiority clinical trial.红外激光灸与传统灸治疗膝骨关节炎的疗效和安全性比较：一项 Zelen 设计的随机对照非劣效性临床试验研究方案。
J Orthop Surg Res. 2023 Dec 2;18(1):922. doi: 10.1186/s13018-023-04408-x.
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Relationship between perceived coercion and perceived justification of coercive measures - secondary analysis of a randomized-controlled trial.感知到的强制与感知到的强制措施正当性之间的关系——一项随机对照试验的二次分析。
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Design, analysis, and interpretation of treatment response heterogeneity in personalized nutrition and obesity treatment research.个性化营养和肥胖治疗研究中治疗反应异质性的设计、分析和解释。
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Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review.与普通实践中随机对照试验招募相关的因素：系统混合研究综述。
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Taking a chance: How likely am I to receive my preferred treatment in a clinical trial?冒险一试：我在临床试验中接受首选治疗的可能性有多大？
Stat Methods Med Res. 2023 Mar;32(3):572-592. doi: 10.1177/09622802221146305. Epub 2023 Jan 10.
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Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial.每日补充 5000IU 维生素 D3 以预防医护人员患流感样疾病：一项实用随机临床试验。
Nutrients. 2022 Dec 30;15(1):180. doi: 10.3390/nu15010180.

本文引用的文献

1
Understanding controlled trials. What is a patient preference trial?理解对照试验。什么是患者偏好试验？
BMJ. 1998 Jan 31;316(7128):360. doi: 10.1136/bmj.316.7128.360.
2
Randomized trial of osteoporosis screening. Use of hormone replacement therapy and quality-of-life results.骨质疏松症筛查的随机试验。激素替代疗法的使用及生活质量结果。
Arch Intern Med. 1997 Oct 13;157(18):2121-5. doi: 10.1001/archinte.157.18.2121.
3
Informed consent: the intricacies.知情同意：错综复杂之处。
BMJ. 1997 Apr 12;314(7087):1059-60. doi: 10.1136/bmj.314.7087.1059.
4
Randomised controlled trial of faecal-occult-blood screening for colorectal cancer.粪便潜血筛查结直肠癌的随机对照试验。
Lancet. 1996 Nov 30;348(9040):1472-7. doi: 10.1016/S0140-6736(96)03386-7.
5
Randomised study of screening for colorectal cancer with faecal-occult-blood test.粪便潜血试验筛查结直肠癌的随机研究。
Lancet. 1996 Nov 30;348(9040):1467-71. doi: 10.1016/S0140-6736(96)03430-7.
6
Randomised consent designs in cancer clinical trials.癌症临床试验中的随机同意设计。
Eur J Cancer. 1995 Nov;31A(12):1934-44. doi: 10.1016/0959-8049(95)00470-x.
7
Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.体外膜肺氧合与传统药物治疗用于新生儿持续性肺动脉高压：一项前瞻性随机研究。
Pediatrics. 1989 Dec;84(6):957-63.
8
Randomized consent designs for clinical trials: an update.临床试验的随机同意设计：最新进展
Stat Med. 1990 Jun;9(6):645-56. doi: 10.1002/sim.4780090611.
9
A new design for randomized clinical trials.一种用于随机临床试验的新设计。
N Engl J Med. 1979 May 31;300(22):1242-5. doi: 10.1056/NEJM197905313002203.

What is Zelen's design?

作者信息

Torgerson D J, Roland M

机构信息

National Primary Care Research and Development Centre, University of York.

出版信息

BMJ. 1998 Feb 21;316(7131):606. doi: 10.1136/bmj.316.7131.606.

DOI:10.1136/bmj.316.7131.606
PMID:9518917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1112637/
Abstract
摘要