Bird L E, Subramanya H S, Wigley D B
Sir William Dunn School of Pathology, University of Oxford, UK.
Curr Opin Struct Biol. 1998 Feb;8(1):14-8. doi: 10.1016/s0959-440x(98)80004-3.
The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.
近期对PcrA DNA解旋酶、NS3 RNA解旋酶和Rep DNA解旋酶的结构测定揭示了它们折叠方式之间的相似性。当结合序列分析、生化分析以及六聚体解旋酶的显微镜研究来审视这些数据时，一幅关于所有解旋酶统一结构和机制的图景正开始浮现。
