Wendt K U, Schulz G E
Institut für Organische Chemie und Biochemie, Freiburg, Germany.
Structure. 1998 Feb 15;6(2):127-33. doi: 10.1016/s0969-2126(98)00015-x.
Isoprenoids comprise a family of more than 23,000 natural products, among them the precursors of cholesterol and taxol. The structures of three isoprenoid-cyclizing enzymes have recently been determined and here are placed in the greater context of isoprenoid biosynthesis. On the basis of reaction mechanisms, a subdivision into class I and class II enzymes is proposed. The chain folds of these enzymes also appear to fall into the same two distinct classes, suggesting that class I and class II enzymes have evolved separately.
类异戊二烯由超过23000种天然产物组成，其中包括胆固醇和紫杉醇的前体。最近已经确定了三种类异戊二烯环化酶的结构，并在此将它们置于类异戊二烯生物合成的更大背景中。基于反应机制，提出将其分为I类和II类酶。这些酶的链折叠似乎也分为同样的两类，这表明I类和II类酶是独立进化的。
