Arensman R M, Stolar C J
J Pediatr Surg. 1979 Dec;14(6):809-13. doi: 10.1016/s0022-3468(79)80271-7.
The inhibitory effect of vitamin A on tumor establishment and growth has been studied in two animal models. The C57L/J hepatoma, when placed in C57L/J mice receiving inoculations of vitamin A, showed slow growth and the hosts had significantly prolonged survival over untreated mice. The V-2 carcinoma, when implanted in the corneas of New Zealand white rabbits receiving injections of vitamin A, showed decreased vascular response in the limbic vessels. The absence of an induced vascular response prevents vascularization of the tumor and subsequent tumor growth. The evidence suggests that vitamin A may exert its inhibitory effect by modifying the normal vascular response to neoplastic tissue.
维生素A对肿瘤形成和生长的抑制作用已在两种动物模型中进行了研究。将C57L/J肝癌接种到接受维生素A注射的C57L/J小鼠体内时，肿瘤生长缓慢，与未治疗的小鼠相比，宿主的存活时间显著延长。将V-2癌植入接受维生素A注射的新西兰白兔角膜中时，其边缘血管的血管反应减弱。诱导血管反应的缺失可防止肿瘤血管化及随后的肿瘤生长。有证据表明，维生素A可能通过改变对肿瘤组织的正常血管反应来发挥其抑制作用。
