Baumeister E, Fernández Cobo M, Pontoriero A, Savy V
Servicio de Virus Respiratorios, Instituto Nacional de Enfermedades Infecciosas, Buenos Aires, Argentina.
Enferm Infecc Microbiol Clin. 1997 Dec;15(10):528-31.
Acute respiratory infection (ARI) are a health care problem as the adenovirus (ADV) has shown to be one of the most frequent viral agents detected in children admitted for mild ARI in the authors medium.
Over a 7-year period (1988-1994) ADV isolated from patients under the age of 5, admitted for mild ARI in hospitals in the city of Buenos Aires (Argentina). All the strains were isolated in HEp-2 cell cultures from nasopharyngeal aspirates in which the presence of ADV was detected by indirect immunofluorescence with monoclonal antibodies. Antigenic characterization was performed by sero- and genome neutralization with restriction enzymes.
The isolates corresponded to the genomic variants of ADV 7i, ADV 7c and to a greater number of ADV 7h. An increase was observed in the quantity of cases in the second half of the year. In the population studied, the most commonly infected were males (67.9%) and patients from 2 months to 1 year in age (89.2%). Sixty-six percent of the cases were severe infections with the length of hospitalization being greater than that of patients normally admitted for mild ARI by other virus and showed a high mortality.
All the above events suggest that the genomic variants detected are highly pathogenic.
急性呼吸道感染（ARI）是一个医疗保健问题，因为在作者所在地区，腺病毒（ADV）已被证明是在因轻度ARI入院的儿童中检测到的最常见病毒病原体之一。
在7年期间（1988 - 1994年），从阿根廷布宜诺斯艾利斯市医院中因轻度ARI入院的5岁以下患者中分离出腺病毒。所有菌株均从鼻咽抽吸物的HEp - 2细胞培养物中分离得到，其中通过单克隆抗体间接免疫荧光检测腺病毒的存在。通过血清中和及用限制性酶进行基因组中和来进行抗原特征分析。
分离株对应于腺病毒7i、腺病毒7c的基因组变体以及更多的腺病毒7h。下半年病例数量有所增加。在所研究的人群中，最常感染的是男性（67.9%）以及2个月至1岁的患者（89.2%）。66%的病例为严重感染，住院时间长于其他病毒导致的轻度ARI正常入院患者，且死亡率较高。
上述所有情况表明检测到的基因组变体具有高度致病性。
