Brann L, Wood J D
Am J Dig Dis. 1976 Aug;21(8):633-40. doi: 10.1007/BF01071956.
In normal siblings of piebald mice, artificial fecal pellets were propelled by peristaltic activity through the large intestine in vitro and were expelled at the anal end. Peristalsis was blocked by lidocaine. Artificial fecal pellets were propelled in the dilated region of the megacolon, but were not propelled in the terminal hypoganglionic segment of the intestine of piebald mice. Retropulsion of artificial fecal pellets occurred in vitro in normal bowel obstructed by a ligature, in the bowel of piebald mice with a narrowed terminal segment, and in the intestine of mice with imperforate anus. The results indicate that the distended portion of the colon of piebald mice is capable of coordinated peristalsis and that accumulation of feces and megacolon are secondary to the terminal obstruction that results from absence of coordinated propulsive activity in the hypoganglionic terminal segment. Reverse peristalsis may be a general response to a distal obstruction.
在花斑小鼠的正常同窝仔中，人工粪便颗粒在体外通过大肠的蠕动活动被推进，并在肛门端排出。蠕动被利多卡因阻断。人工粪便颗粒在巨结肠的扩张区域被推进，但在花斑小鼠肠道的终末低神经节段未被推进。人工粪便颗粒的逆推进在体外发生于被结扎阻塞的正常肠段、终末段变窄的花斑小鼠肠段以及肛门闭锁小鼠的肠道中。结果表明，花斑小鼠结肠的扩张部分能够进行协调蠕动，并且粪便积聚和巨结肠是由于低神经节终末段缺乏协调推进活动导致的终末阻塞的继发结果。逆蠕动可能是对远端阻塞的一种普遍反应。
