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合成三萜类和甾体β-D-吡喃木糖基-(1→6)-β-D-吡喃葡萄糖苷的生物活性

Biological activities of synthetic triterpenoid and steroid beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranosides.

作者信息

Takechi M, Uno C, Tanaka Y

机构信息

Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.

出版信息

Phytochemistry. 1997 Jan;44(2):299-303. doi: 10.1016/s0031-9422(96)00547-x.

Abstract

Comparisons of the activities of diosgenyl, methyl glycyrrhetinate or digitoxigenyl 3-O-beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranoside with those of our previous glycosides supported our assumptions that both haemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all haemolytic triterpenoid saponins show no antifungal activity, and that both antiviral and anti-ATPase activities of cardiac glycosides having a (1-->6) sugar linkage are much lower than those of the others.

摘要

薯蓣皂苷元、甘草次酸甲酯或洋地黄毒苷元3 - O - β - D - 吡喃木糖基 - (1→6) - β - D - 吡喃葡萄糖苷与我们之前的糖苷活性比较,支持了我们的假设:甾体皂苷的溶血和抗真菌活性通常彼此平行,而几乎所有溶血三萜皂苷均无抗真菌活性;具有(1→6)糖键的强心苷的抗病毒和抗ATP酶活性远低于其他强心苷。

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