Takechi M, Uno C, Tanaka Y
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan.
Biol Pharm Bull. 1998 Nov;21(11):1234-5. doi: 10.1248/bpb.21.1234.
Comparisons of the biological activities of diosgenyl, methyl glycyrrhetinate or digitoxigenyl 3-O-beta-L-xylopyranosyl-(1-->6)-beta-D-glucopyranoside with those of other previously tested glycosides confirmed our assumption that both the hemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all hemolytic triterpenoid saponins and nonhemolytic ones have no antifungal activity, and that cardiac diglycosides having a (1-->4) sugar linkage have stronger activities than those with a (1-->6) or a (1-->2) linkage. On the other hand, the case of the diosgenyl 3-O-beta-L-xylopyranosyl-(1-->6)-alpha-D-glucopyranoside didn't conform to the above assumption, but those of methyl glycyrrhetinate and digitoxigenyl did.
将薯蓣皂苷元、甘草次酸甲酯或洋地黄毒苷元3 - O -β - L -吡喃木糖基 -（1→6）-β - D -吡喃葡萄糖苷的生物活性与其他先前测试过的糖苷的生物活性进行比较，证实了我们的假设：甾体皂苷的溶血活性和抗真菌活性通常彼此平行，而几乎所有溶血三萜皂苷和非溶血三萜皂苷均无抗真菌活性，并且具有（1→4）糖键的强心二糖苷比具有（1→6）或（1→2）键的强心二糖苷活性更强。另一方面，薯蓣皂苷元3 - O -β - L -吡喃木糖基 -（1→6）-α - D -吡喃葡萄糖苷的情况不符合上述假设，但甘草次酸甲酯和洋地黄毒苷元的情况符合。
