Landry M L, Lucia H L, Hsiung G D, Pronovost A D, Dann P R, August M J, Mayo D R
Am J Med. 1982 Jul 20;73(1A):143-50. doi: 10.1016/0002-9343(82)90080-8.
The pathogenesis of genital infection with three different strains of herpes simplex virus type 1 (HSV-1) and three strains of herpes simplex virus type 2 (HSV-2) was compared in the guinea pig. Strain differences in severity of clinical disease and mortality were noted. HSV-1 strains generally produced milder disease than HSV-2. Both HSV-1 and HSV-2 infections resulted in acute and chronic changes in the cervix. Virus recovery during latent infection was more frequently obtained from the spinal cord in HSV-1-infected animals and from lumbosacral ganglia in HSV-2-infected animals. Systemic treatment with acyclovir, after the onset of clinical disease, had minimal, if any, effect on genital infection with HSV-1 (NYU-78), but similar treatment of HSV-2 (WT-186) infection resulted in decreased lesion scores, paralysis, and mortality during acute infection. A reduction in virus isolations from lumbosacral ganglia was noted during both acute and latent infection with HSV-2 (WT-186) in the acyclovir-treated groups.
在豚鼠中比较了三种不同的1型单纯疱疹病毒（HSV-1）毒株和三种2型单纯疱疹病毒（HSV-2）毒株引起生殖器感染的发病机制。注意到临床疾病严重程度和死亡率方面的毒株差异。HSV-1毒株通常比HSV-2引起的疾病更轻。HSV-1和HSV-2感染均导致子宫颈出现急性和慢性变化。在潜伏感染期间，HSV-1感染动物的脊髓中更频繁地检测到病毒，而HSV-2感染动物的腰骶神经节中更频繁地检测到病毒。临床疾病发作后用阿昔洛韦进行全身治疗，对HSV-1（NYU-78）引起的生殖器感染几乎没有影响，但对HSV-2（WT-186）感染进行类似治疗可降低急性感染期间的病变评分、瘫痪和死亡率。在阿昔洛韦治疗组中，HSV-2（WT-186）急性和潜伏感染期间，从腰骶神经节分离出的病毒数量均有所减少。
