通过MIB-1免疫组织化学评估成釉细胞纤维瘤及颌骨相关病变与成釉细胞纤维肉瘤相比的生长潜能。
Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma.
作者信息
Sano K, Yoshida S, Ninomiya H, Ikeda H, Ueno K, Sekine J, Iwamoto H, Uehara M, Inokuchi T
机构信息
Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
出版信息
J Oral Pathol Med. 1998 Feb;27(2):59-63. doi: 10.1111/j.1600-0714.1998.tb02094.x.
Specimens from two ameloblastic fibromas (including one recurrent case), two ameloblastic fibro-odontomas, and one ameloblastic fibrosarcoma were subjected to investigation by MIB-1 immunohistochemistry in order to elucidate the growth potential of these tumors. MIB-1 labeling indices in the epithelial component of these tumors ranged from 2.9 to 7.5%, whereas those in the mesenchymal component ranged from 1.5 to 13.5%. Of these, labeling indices in the mesenchymal component of the recurrent ameloblastic fibroma and ameloblastic fibrosarcoma were quite high. These findings suggest that evaluation of growth potential in ameloblastic fibroma and related lesions could be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.
选取了两个成釉细胞纤维瘤标本（包括一例复发病例）、两个成釉细胞纤维牙瘤标本以及一个成釉细胞纤维肉瘤标本，通过MIB - 1免疫组织化学进行研究，以阐明这些肿瘤的生长潜能。这些肿瘤上皮成分的MIB - 1标记指数范围为2.9%至7.5%，而间充质成分的标记指数范围为1.5%至13.5%。其中，复发性成釉细胞纤维瘤和成釉细胞纤维肉瘤间充质成分的标记指数相当高。这些发现表明，评估成釉细胞纤维瘤及相关病变的生长潜能可能有助于了解肿瘤的侵袭性并选择合适的手术方法。
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